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ProteomicsAnterior Gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy-induced senescence escape.
Among the different chemotherapies available, genotoxic drugs are widely used. In response to these drugs, particularly doxorubicin, tumor cells can enter into senescence. Chemotherapy-induced senescence (CIS) is a complex response. Long described as a definitive arrest of cell proliferation, we and...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028073 | Pride
Chemotherapy Agr2 Senescence 
ProteomicstRNA Biogenesis and Specific Aminoacyl-tRNA Synthetases Regulate Senescence Stability Under the Control of mTOR
Oncogenes or chemotherapy treatments trigger the induction of suppressive pathways such as apoptosis or senescence. Senescence was initially defined as a definitive arrest of cell proliferation but recent results have shown that this mechanism is also associated with cancer progression and chemother...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029535 | Pride
Chemotherapy Trna Er stress Senescence P21 Mtor 
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