Sort   by:  
 Page size 
TranscriptomicsTranscriptional profiling by array of human primary keratinocytes to find new genes regulated by p21
Our goal is to find new genes regulated by p21 in human primary cells . To get it we carried out a gene expression profiling in two different models, human myeloid leukemia K562 cells and human keratinocytes both of them with conditional expression of p21. In order to identify genes specifically mo...
ORGANISM(S): Homo sapiens 
2012-04-30 | E-MEXP-3430 | biostudies-arrayexpress
Transcriptomicsp21 as a transcriptional co-represor of S-phase and mitotic control genes-kp21
Our goal is to find new genes regulated by p21 in human primary cells . To get it we carried out a gene expression profiling in two different models, human myeloid leukemia K562 cells and human keratinocytes both of them with conditional expression of p21. In order to find genes regulated by p21 in...
ORGANISM(S): Homo sapiens 
2012-05-30 | E-MEXP-3431 | biostudies-arrayexpress
TranscriptomicsLoss of p21 expression enhances DNA damage, cholestasis and hepatocarcinogenesis in the liver
Overexpression of p21 in NEMOM-NM-^Thepa animals protects against DNA damage, acceleration of hepatocarcinogenesis and cholestasis. As strengthened by our LPS stimulation experiments, we identified a novel protective role of p21 against DNA damage. Expression profiling of livers from wild type, NEMO...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-61100 | biostudies-arrayexpress
TranscriptomicsEffect of p21 overexpression on skeletal muscle mRNA expression.
For additional details see Bongers et al, Spermine Oxidase Maintains Basal Skeletal Muscle Gene Expression and Fiber Size, and Is Strongly Repressed by Conditions that Cause Skeletal Muscle Atrophy . Am J Physiol Endocrinol Metab. 2014 [under review] Bilateral tibialis anterior muscles of C57BL/6 m...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-63007 | biostudies-arrayexpress
TranscriptomicsEffect of CDK8/19 inhibitor Senexin A on p21-regulated gene expression in human HT1080 p21-9 cells with IPTG-inducible p21
p21 (CDKN1A) expression from an IPTG-inducible promoter in HT1080 p21-9 cells was previously shown to inhibit a set of genes, many of which are involved in cell cycle progression, and to upregulate another set of genes, some of which have been implicated in cancer and age-related diseases. We have n...
ORGANISM(S): Homo sapiens 
2012-08-12 | E-GEOD-39464 | biostudies-arrayexpress
TranscriptomicsMicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenot...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-14831 | biostudies-arrayexpress
GenomicsPasteuria ramosa strain:P21 | isolate:P21
Pasteuria ramosa Genome sequencing and assembly (isolate P21)
PRJNA1064691 | ENA
GenomicsClostridioides difficile P21
Clostridioides difficile P21 Genome sequencing and assembly
PRJNA85987 | ENA
ModelsBarr2017 - Dynamics of p21 in hTert-RPE1 cells
Barr2017 - Dynamics of p21 in hTert-RPE1 cells This deteministic model reveals that a bistable switch created by Cdt2, promotes irreversible S-phase entry by keeping p21 levels low, prevents premature S-phase exit upon DNA damage This model is described in the article: DNA damage during S-...
2024-09-02 | BIOMD0000000660 | BioModels
TranscriptomicsApoptosis induced by Piroxicam/Cisplatin combined treatment is triggered by p21 in mesothelioma
Here we report that piroxicam/cisplatin combined treatment exerts an apoptotic effect on mesothelioma cells. Genome-wide transcriptome analyses lead us to identify p21 as the possible apoptosis mediator acting as downstream target of the piroxicam/cisplatin treatment. To analyze the potential therap...
ORGANISM(S): Homo sapiens 
2011-11-20 | E-GEOD-22445 | biostudies-arrayexpress
Sort   by:  
 Page size