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TranscriptomicsGene Expression analysis of Kc and Mbn2 cell lines from Drosophila melanogaster.
Comparison of gene expression between Kc and Mbn2 cell lines derived from Drosophila melanogaster. Microarray analysis was performed with two biological replicates for each cell line. Each array contains 15,634 Drosophila genes in duplicate with 12, 60 mer probes per gene.
ORGANISM(S): Drosophila melanogaster 
2010-05-19 | E-GEOD-15660 | biostudies-arrayexpress
GenomicsDistribution of insulator proteins CP190, dCTCF, Su(Hw) and Mod(mdg4)2.2 in Drosophila S2 cells in the presence or absence of dPARP inhibitor 3AB
We mapped the localization of insulator proteins in Drosophila S2 cells in the presence or absence of 12mM of 3AB. We found that inhibition of PARylation affects DNA binding of insulator proteins only at a small subsets of genomic sites. Examination of genomic occupancy for insulator proteins in S2 ...
ORGANISM(S): Drosophila melanogaster 
2013-09-15 | E-GEOD-41354 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding profiles of Drosophila melanogaster insulator proteins in Kc and Mbn2 cells
ChIP-chip experiments with NimbleGen whole-genome tiling arrays to compare Su(Hw), dCTCF, BEAF, and CP190 localization on DNA in Kc and Mbn2 cells revealed that BEAF is a third subclass of CP190-containing insulators. The DNA binding proteins, Su(Hw), dCTCF, and BEAF show unique distribution patter...
ORGANISM(S): Drosophila melanogaster 
2010-05-19 | E-GEOD-15661 | biostudies-arrayexpress
GenomicsDistribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq]
Chromatin insulators are DNA protein complexes that mediate inter and intra chromosomal interactions. Boundary Element Associated Factor- 32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression. We find that mutations in BEAF-32 are ...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36735 | biostudies-arrayexpress
GenomicsBEAF-32 insulator regulates gene expression of genes involved in cell polarity and neoplastic growth.
This SuperSeries is composed of the following subset Series: GSE36735: Distribution of Drosophila insulator protein BEAF-32 in Wing imaginal tissue (Wildtype) [ChIP-seq] GSE36736: Genome wide transcriptional profiling of BEAF-32 in wing imaginal tissues of wildtype and mutants [expresion array] Refe...
ORGANISM(S): Drosophila melanogaster 
2012-07-05 | E-GEOD-36737 | biostudies-arrayexpress
GenomicsDistribution of Drosophila insulator proteins DREF in Drosophila Kc167 cells
Here we map the localization of DREF Drosophila replication related element binding factor in Drosophila Kc cells. Examination of genomic occupancy for DREF, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740 and GSE32584). The GSM number for the...
ORGANISM(S): Drosophila melanogaster 
2013-05-01 | E-GEOD-39664 | biostudies-arrayexpress
GenomicsInsights into the epigenomic landscape of the human malaria vector Anopheles gambiae
We characterize the epigenome of the human malaria vector Anopheles gambiae in midgut cells by mapping the distribution and levels of two post-translational histone modifications, H3K27ac and H3K27me3. These histone profiles were then correlated with levels of gene expression obtained by RNA-seq. Ch...
ORGANISM(S): Anopheles gambiae 
2014-09-04 | E-GEOD-59773 | biostudies-arrayexpress
GenomicsDistribution of Drosophila insulator proteins Mod(mdg4) and L(3)mbt in Kc cells
Here we map the localization of Mod(mdg4), including Mod(mdg4)2.2 specific and Mod(mdg4) common to all isoforms, to chromatin insulators, as well as the lethal-3 malignant brain tumor protein in Drosophila Kc cells. examination of genomic occupancy for Mod(mdg4)2.2, Mod(mdg4)BTB (all isoforms), and ...
ORGANISM(S): Drosophila melanogaster 
2012-06-18 | E-GEOD-36393 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Kc cells from Drosophila melanogaster during ecdysone treatment and CP190 knockdown
This study examines the changes in genes expression that occur in Drosophila melanogaster during the ecdysone response as well as during RNAi knockdown of the insulator protein, CP190. Analysis was performed in Kc cells after 0, 3, and 48 hours of ecdysone treatment in the presence of either contro...
ORGANISM(S): Drosophila melanogaster 
2011-10-13 | E-GEOD-30686 | biostudies-arrayexpress
GenomicsDistribution of histone modificiation H3K27me3 in Drosophila Kc cells, comparison with dCTCF knockdown
Here we map the localization of H3K27me3 in Drosophila Kc cells, as well as in Drosophila Kc cells wherein dCTCF is knock down. examination of genomic occupancy for H3K27me3, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740)
ORGANISM(S): Drosophila melanogaster 
2012-06-18 | E-GEOD-37444 | biostudies-arrayexpress
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