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Transcriptomicshourglass
The observation that animal morphology tends to be conserved during the embryonic phylotypic period led to the proposition that embryogenesis diverges more extensively early and late than in the middle, known as the hourglass model. This pattern of conservation is thought to reflect a major constrai...
ORGANISM(S): Drosophila simulans 
2011-02-18 | E-MTAB-404 | biostudies-arrayexpress
TranscriptomicsShort and Long RNA sequencing of human mature erythrocytes
We employed high-throughput sequencing of both short (~18-24nt) and long (>200nt) RNAs in human erythrocytes. We obtained blood from five healthy individuals for the short (small) RNA-seq library preparations and blood from three individuals for the long RNA-seq library preparations. We identified a...
ORGANISM(S): Homo sapiens 
2015-11-19 | E-GEOD-63703 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. The expression and role of microRNAs (miRNA) has not been studied in IPF. Using miRNA expression microarrays we identified 46 differentially ex...
ORGANISM(S): Homo sapiens 
2010-04-23 | E-GEOD-13316 | biostudies-arrayexpress
UnknownSymptom trajectories and psychosis onset in a clinical high-risk cohort: the relevance of subthreshold thought disorder.
Not available
S-EPMC4254175 | biostudies-literature
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [PAR-CLIP]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39682 | biostudies-arrayexpress
TranscriptomicsFMR1 targets distinct mRNA sequence elements to regulate protein expression [Affymetrix]
Fragile-X Syndrome (FXS) is a multi-organ disease leading to mental retardation, macro-orchidism in males, and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASD). FXS is typically caused by the loss of FRAGILE...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-39504 | biostudies-arrayexpress
UnknownBaseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort.
Not available
S-EPMC5893280 | biostudies-literature
UnknownCelFDrive: Multimodal fluorescence microscopy dataset of mitotic stages in human RPE-1 cells (SiR-DNA) with expert bounding-box annotations for deep-learning object detection
Not available
S-BIAD3980 | bioimages
TranscriptomicsHuman Promoters Are Intrinsically Directional
Divergent transcription, in which reverse-oriented transcripts occur upstream of eukaryotic promoters in regions devoid of annotated genes, has been suggested to be a general property of active promoters. Here we show that the human basal RNA polymerase II transcriptional machinery and core promoter...
ORGANISM(S): Homo sapiens 
2015-01-16 | E-GEOD-63872 | biostudies-arrayexpress
GenomicsLocation specific ACVR1, FGFR1 and TP53 mutations in pediatric glioblastomas in conjunction with H3.3 K27M.
Recurrent somatic H3 K27M mutations characterize midline pediatric high-grade astrocytomas (pHGAs). In 40 treatment-naïve midline pHGAs we find additional somatic mutations specific to tumor location. Gain-of-function mutations in ACVR1 occur in tumors of the pons in conjunction with H3.1K27M, whil...
EGAS00001000720 | EGA
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