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Genomicsc-Myc Transcriptionally Amplifies Sox2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells [ChIP-Seq]
An immortalized multipotent otic progenitor (iMOP) cell was generated by transient expression of c-Myc in Sox2-expressing otic progenitor cells. The procedure activated endogenous c-Myc expression in the cells and amplified existing Sox2-dependent transcripts to promote self-renewal. Downregulation ...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-62513 | biostudies-arrayexpress
UnknownSomatic mutations predict poor outcome in patients with myelodysplastic syndrome after hematopoietic stem-cell transplantation.
Not available
S-EPMC4207878 | biostudies-literature
UnknownMice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.
Not available
S-EPMC5175141 | biostudies-literature
UnknownPSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss.
Not available
S-EPMC4686969 | biostudies-literature
UnknownGenome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
Not available
S-EPMC4572074 | biostudies-literature
UnknownAntibody to HSV gD peptide induced by vaccination does not protect against HSV-2 infection in HSV-2 seronegative women.
Not available
S-EPMC5426618 | biostudies-literature
TranscriptomicsIdentification of Yeast Genes that Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics
Abstract: Chemogenomic fitness assays were combined with a transcriptome analysis to understand both the mode of action and the mechanisms of resistance to Chitosan oligosaccharides (COS). COS are deacetylated chitin compounds, with antimicrobial properties, that are presumed to act by disrupting t...
ORGANISM(S): Saccharomyces cerevisiae 
2012-12-22 | E-GEOD-32888 | biostudies-arrayexpress
TranscriptomicsRas Affects Filamentous Growth in Saccharomyces cerevisiae Solely Through Regulation of Protein Kinase A
To assess the relative contributions of the PKA and MAPK pathways in Ras stimulation of filamentation, we examined the change in transcriptional profile following activation of Ras in strains in which one of these two pathways has been severed. These arrays contain the experiments involving WT strai...
ORGANISM(S): Saccharomyces cerevisiae 
2007-08-18 | E-GEOD-8805 | biostudies-arrayexpress
TranscriptomicsDIP-chip from Cbf1, Leu3, Pho2, Pho4, Rap1, Rox1, and Swi5
DNA Immunoprecipitation was performed using purified, naked, genomic DNA and purified recombinant DNA binding domains for S. cerevisiae transcription factors (Cbf1, Leu3, Pho2, Pho4, Rap1, Rox1, and Swi5) and then competitively hybridized against input DNA on NimbleGen 385k whole-genome, 32bp, tilin...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-15 | E-GEOD-13751 | biostudies-arrayexpress
TranscriptomicsA library of yeast transcription factor motifs
The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 ...
ORGANISM(S): Saccharomyces cerevisiae 
2008-12-26 | E-GEOD-12349 | biostudies-arrayexpress
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