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MetabolomicsSpatiotemporal determination of metabolite activities in the corneal epithelium on a chip
The corneal epithelial barrier maintains the metabolic activities of the ocular surface by regulating membrane transporters and metabolic enzymes responsible for the homeostasis of the eye as well as the pharmacokinetic behavior of drugs. Despite its importance, no established biomimetic in vitro me...
2021-07-13 | MTBLS2274 | MetaboLights
TranscriptomicsmicroRNA Expression of mice corneal endothelia
MicroRNA profile comparison of the corneal endothelium of young and old mice: implications for senescence of the corneal endothelium We collected the corneal endothelia from 30 mice aged 10-13 weeks and the corneal endothelia from 30 mice aged 2 years. The samples were pooled into six groups (y1, y2...
ORGANISM(S): Mus musculus 
2013-12-27 | E-GEOD-48094 | biostudies-arrayexpress
TranscriptomicsIdentification of Novel Molecular Markers through Transcriptomic Analysis in Human Fetal and Adult Corneal Endothelial Cells
Corneal endothelium is composed of a monolayer of corneal endothelial cells (CECs) in the inner layer of cornea, which is essential for maintaining corneal transparency. In order to better characterize CECs in different developmental stages, we profiled mRNA transcriptomes in human fetal and adult c...
ORGANISM(S): Homo sapiens 
2013-01-08 | E-GEOD-41616 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of cultured corneal endothelial cells as a validation for their use in cell-replacement therapy
The corneal endothelium plays a primary role in maintaining corneal homeostasis and clarity, and must be surgically replaced with allogenic donor corneal endothelium in the event of visually significant dysfunction. However, a worldwide shortage of donor corneal tissue has led to a search for altern...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-65991 | biostudies-arrayexpress
GenomicsEpigenome analysis of normal human corneal endothelium and corneal endothelium from FECD patients
Epigenome analysis of normal human corneal endothelium and corneal endothelium from FECD patients
PRJNA817425 | ENA
GenomicsEarly-stage Col8a2Q455K mutant mouse corneal endothelium Late-stage Col8a2Q455K mutant mouse corneal endothelium Early-stage wild-type mouse corneal endothelium Late-stage wild-type mouse corneal endothelium
Early-stage Col8a2Q455K mutant mouse corneal endothelium Late-stage Col8a2Q455K mutant mouse corneal endothelium Early-stage wild-type mouse corneal endothelium Late-stage wild-type mouse corneal endothelium
PRJNA1304433 | ENA
ProteomicsCigarette smoke induces changes in the basement membrane proteins of the corneal endothelium
Proteome profiling was performed to investigate changes at a molecular level in the mouse corneal endothelium (CE) along with the basement membrane exposed to cigarette smoke (CS). Pregnant mice (gestation days 18-20) were placed in a whole-body exposure smoking chamber and a few days later pups wer...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020036 | Pride
Mass-spectrometry Corneal endothelium Basement membrane Proteome Cigarette smoke 
GenomicsGenome-Wide Binding of Ehf in mouse corneal epithelium
The cornea, composed of epithelium, stroma and endothelium, protects the anterior compartment of the eye from damage and allows transmission of light into the eye. While well described morphologically, no studies have investigated the global gene expression changes in the cornea throughout the mous...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-44741 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary cultures from mouse cornea vs those of the adult and 10-day postnatal mouse cornea to elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells
To elucidate biological processes underlying the keratocyte, fibroblast, and myofibroblast phenotypes of corneal stromal cells, the gene expression patterns of these primary cultures from mouse cornea were compared with those of the adult and 10-day postnatal mouse cornea.
ORGANISM(S): Mus musculus 
2007-10-31 | E-GEOD-1867 | biostudies-arrayexpress
TranscriptomicsCorneal Gene Expression Analysis
Transplantation of amniotic membrane-expanded limbal epithelium (AMLE) in place of donor tissue grafts results in significantly improved outcomes for patients suffering from severe limbal stem cell deficiency; however the reasons for such superior results are unclear. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-56421 | biostudies-arrayexpress
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