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MetabolomicsEVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
TranscriptomicsHuman cortical organoids. Chronic treatment with GSK3 inhibitor CHIR99021. Bulk RNAseq.
Here we used human cortical brain organoids to probe the longitudinal impact of GSK3 inhibition through multiple developmental stages. Chronic GSK3 inhibition increased the proliferation of neural progenitors and caused massive derangement of cortical tissue architecture. Cortical organoids were dif...
ORGANISM(S): Homo sapiens 
2020-06-04 | E-MTAB-8325 | biostudies-arrayexpress
ProteomicsATM-knockout on total and phosphorylation proteomes of cortical brain organoids
ATM (ataxia telangiectasia mutated) kinase is crucial to a wide range of human developmental disorders and adult/pediatric malignancies. Its mutations are causally tied to ataxia telangiectasia, a multi-systemic congenital disorder mainly affecting brain and blood systems. We generated 4 separate ...
ORGANISM(S): Homo sapiens (Human) 
2024-07-25 | PXD041699 | Pride
Phosphorylation proteome  proteome  atm kinase  cortical brain organoids 
ProteomicsProteomics characterisation of induced pluripotent stem cells and cortical brain organoids.
A method was developed to reproducibly produce neural retina and cortical brain regions from confluent cultures of stem cells. The spontaneously generated cortical organoids were isolated and cultured in suspension conditions for maturation. Proteomic analysis of both the original induced pluripoten...
ORGANISM(S): Homo sapiens (Human) 
2022-05-06 | PXD025933 | Pride
Cortical Stem cell Proteomics Brain Neural retina Organoid Pluripotent 
TranscriptomicsscRNA-seq data from GLI3 KO in brain organoids
To study the effect of GLI3 knockout in brain organoids, we collected scRNA-seq data from 45 day old brain organoids with GLI3 KO
ORGANISM(S): Homo sapiens 
2022-08-19 | E-MTAB-11997 | biostudies-arrayexpress
TranscriptomicsRNA-seq of INPP5E mutant cortical organoids against control organoids
Primary cilia act as antennas in cell-cell signalling and are crucial for nervous system development. We explored their role in the development of the human cerebral cortex using organoids defective for the ciliary gene INPP5E. We investigated the transcription profile of control and INPP5ED477N/D47...
ORGANISM(S): Homo sapiens 
2022-06-06 | E-MTAB-11437 | biostudies-arrayexpress
TranscriptomicsMultiome experiment of the neuroepithelial stage of brain organoid developement
To investigate the heterogeneity during the neuroepithelial stage of organoid development, we performed a multiome experiment on day 15-18 old brain organoids
ORGANISM(S): Homo sapiens 
2022-10-03 | E-MTAB-12004 | biostudies-arrayexpress
TranscriptomicsCROP-seq of 2 month old brain organoids
To investigate the influence of transcription factor knockouts in cell fate decision-making, we performed a CROP-seq screen of 20 transcription factors in brain organoids.
ORGANISM(S): Homo sapiens 
2022-08-18 | E-MTAB-11999 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Human Cortical Organoids Treated with Ciprofloxacin versus Untreated Controls
Human cortical organoids (hCOs) were employed to examine the developmental neurotoxic effects of ciprofloxacin (CPFX). Organoids were subjected to chronic exposure to low doses of CPFX for two weeks, while untreated organoids served as controls. Assessments included mitochondrial function, reactive ...
ORGANISM(S): Homo sapiens 
2026-03-31 | E-MTAB-16792 | biostudies-arrayexpress
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