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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
MetabolomicsMetabolomic Profiling of Human Pluripotent Stem Cell Differentiation into Lung Progenitors
Not available
ORGANISM(S): Homo sapiens 
ST002055 | MetabolomicsWorkbench
MetabolomicsStirred suspension bioreactors maintain naïve pluripotency of human pluripotent stem cells (hPSCs)
Not available
ORGANISM(S): Homo sapiens 
ST001377 | MetabolomicsWorkbench
MetabolomicsMetabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells
Not available
ORGANISM(S): Mus musculus 
ST000003 | MetabolomicsWorkbench
TranscriptomicsExpression data from human pluripotent stem cells and differentiated cells treated with pluripotent-specific inhibitors
The use of human pluripotent stem cells (hPSCs) in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells. Here we performed a high-throughput screen of over 52,000 small molecules, and identified 15 highly selective cytotoxic inhibitors of hPSCs (PluriSIns). Cellular ...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-37040 | biostudies-arrayexpress
TranscriptomicsHuman oocytes reprogram adult somatic cells to pluripotent stem cells [Illumina]
The stem cell lines were generated according to the principle described in Noggle et al., Nature 2011, Oct 5;478(7367):70-5. doi: 10.1038/nature10397. Title: Human oocytes reprogram somatic cells to a pluripotent state. Abstract: The exchange of the oocyte's genome with the genome of a somatic cel...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-60360 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Illumina, snp)
Genotyping was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Seventeen undifferentiated human embryonic stem cell lines and 11 human induced pluripotent stem cells were analyzed. Expanded descriptions of methods used a...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-35157 | biostudies-arrayexpress
TranscriptomicsThe NIH Human Pluripotent Stem Cell Database (Illumina, methylation)
Methylation profiling was performed on DNA samples matched to the RNA samples included in the NIH Human Pluripotent Stem Cell Database (Series GSE32923). Nineteen undifferentiated human embryonic stem cell lines and 5 human induced pluripotent stem cells were analyzed. Expanded descriptions of metho...
ORGANISM(S): Homo sapiens 
2012-10-31 | E-GEOD-34869 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of self-renewing human pancreatic progenitors derived from pluripotent stem cells
Human pluripotent stem cells were differentiated into PDX1+/NKX6-1+ Pancreatic Progenitors (PPd15 cells), which were subsequently captured and expanded in culture. These culture Pancreatic Progenitors (cPP cells) were capable of self-renewal and could be passaged up to 20 times. Furthermore, cPP cel...
ORGANISM(S): Homo sapiens 
2017-06-06 | E-MTAB-5731 | biostudies-arrayexpress
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