Sort   by:  
 Page size 
ProteomicsMulti-compartment quantitative proteomics revealing potential mechanisms underlying the treatment effects of mesenchymal-derived extracellular vesicles in a monkey model of cortical injury
Cortical injury frequently causes motor dysfunction, significantly impairing activities of daily living, and currently, there are no effective therapeutic options available. Previous studies demonstrated that intravenous infusion of mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) e...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2026-06-15 | PXD059286 | Pride
Mesenchymal stromal cell-derived extracellular vesicles Cortical injury Rhesus macaque Brain tissue Plasma Csf Lc-ms/ms 
TranscriptomicsThe unique molecular signature of cortical tissue injury in Multiple Sclerosis
In the present study we addressed several questions related to the mechanisms of cortical injury. We analyzed genome wide gene expression by microarrays, comparing active multiple sclerosis lesions with highly inflammatory lesions of chronic tuberculous meningitis, with neurodegenerative lesions of ...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-32645 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat ipsilateral rat hippocampus 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls
RNA samples were prepared from ipsilateral rat hippocampi 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls. For details please see Matzilevich et al., J Neurosci Res 2002 Mar 1;67(5):646-63.
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-1911 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mice and rats at different time points after moderate levels of brain injury to identify candidate molecular pathways induced by brain injury.
Summary: Brain trauma is a major cause of morbidity and mortality, both in adult and pediatric populations. Much of the functional deficit derives from delayed cell death resulting from induction of neurotoxic factors that overwhelm endogenous neuroprotective responses. Hypothesis: Gene expression p...
ORGANISM(S): Rattus norvegicus 
2007-11-22 | E-GEOD-2392 | biostudies-arrayexpress
ProteomicsLFQ proteomics of isolated GABAergic interneurons from mouse models of traumatic brain injury
Posttraumatic epilepsy (PTE) is a major public health concern and strongly contributes to human epilepsy cases worldwide. However, their effective treatment and prevention remains a matter of intense research. The present study provides new insights into the GABAA-receptor-stabilizing protein ubiqui...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-14 | PXD031368 | JPOST Repository
ProteomicsGFAP and MBP peptides in Traumatic Brain Injury
Glial fibrillary acidic protein (GFAP) is the major intermediate filament III protein of astroglia cells and is upregulated in astrogliosis following traumatic brain injury (TBI). Here we reported that GFAP is truncated at both the C- and N-terminals by cytosolic protease calpain to GFAP breakdown p...
ORGANISM(S): Homo Sapiens 
2022-07-18 | PXD026550 | panorama
TranscriptomicsGene expression profiles after traumatic brain injury
Time dependent-profiles in the gene expression level following lateral moderate fluid percussion injury in the rat brain We used microarray to elucidate relationship between the alteration of gene expression levels and the progression of brain damages following traumatic brain injury. To examine the...
ORGANISM(S): Rattus norvegicus 
2010-12-07 | E-GEOD-24047 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.
Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress
TranscriptomicsMicroarray Analysis Gene Expression Profiles in Laryngeal Muscle After Recurrent Laryngeal Nerve Injury
The pathophysiology of recurrent laryngeal nerve (RLN) transection injury is rare in that it is characteristically followed by a high degree of spontaneous reinnervation, with reinnervation of the laryngeal adductor complex (AC) preceding that of the abducting posterior cricoarytenoid (PCA) muscle. ...
ORGANISM(S): Rattus norvegicus 
2016-07-01 | E-GEOD-72361 | biostudies-arrayexpress
ProteomicsTemporally & Spatially-Resolved Microproteomics and MALDI MSI Lipidomic Analysis for Traumatic Brain Injury
Using an experimental TBI rat model of mild/moderate Controlled Cortical Impact (CCI) injury, we combined large-scale proteomics identification and relative quantification using Spatially-Resolved Microproteomics with MALDI MS Imaging of Lipids. Spatially by studying ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-06-19 | PXD011262 | Pride
Spatiotemporal microproteomics Macrophage Traumatic brain injury Long-chain acylcarnitine Astrocyte Substantia nigra 
Sort   by:  
 Page size