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ProteomicsSpatial proteomics reveals distinct protein patterns in a lissencephaly-like cortical migration disorder caused by LIN28A overexpression and WNT activation
Developmental signalling pathways act in stage and tissue dependent relation and mis-activation can drive tumour formation. The RNA-binding protein LIN28A maintains stemness and is overexpressed in embryonal brain tumours. Activating mutations of CTNNB1 - the WNT pathway effector - have been reporte...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD053649 | Pride
Cortical migration disorder Ctnnb1 Spatial proteomics Lin28a 
TranscriptomicsBcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c
During neocortical development, neurons undergo polarization, oriented migration, and layer type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here we show that the transcription factor Bcl11a regulates polarity and migration of uppe...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-52827 | biostudies-arrayexpress
ProteomicsECE2 regulates Neurogenesis and Neuronal Migration during Cortical Development.
During embryonic development, the cerebral cortex is equipped with excitatory projection and inhibitory interneurons that migrate in organized layers. Periventricular heterotopia (PH) is a rare and heterogeneous disorder in which a subpopulation of new-born projection neurons fails to initiate their...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD015571 | Pride
Ce2 Periventricular heterotopia Cerebral organoids Embryonic development 
TranscriptomicsWild type vs. Nova2 KO mouse E14.5 cortex RNA
To assess the requirement of Nova2 for alternative processing of RNA in the developping brain. Neuronal migration leads to a highly organized laminar structure in the mammalian brain and its mis-regulation causes lissencephaly, behavioral and cognitive defects. Reelin signaling, mediated in part by ...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-22758 | biostudies-arrayexpress
TranscriptomicsGlobal developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects
Proper cortical development relies on the balance of neuronal migration and proliferation. We investigated the gene expression differences of mouse knock-outs for Lissencephaly in humans. Our analysis suggests that gene expression and pathway analysis in mouse models of a similar disorder or within ...
ORGANISM(S): Mus musculus 
2012-01-26 | E-GEOD-35366 | biostudies-arrayexpress
TranscriptomicsGene expression in astrocytes upon sustained GSK-3 inhibition by small molecule
In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with e...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-25770 | biostudies-arrayexpress
ProteomicsDeciphering the Neurological Puzzle in ALG13-CDG Through Cutting-Edge Brain Organoid Modeling
Asparagine-linked glycosylation 13 (ALG13) is an X-linked congenital disorder of glycosylation (CDG) with limited treatment options and mechanistic understanding. Investigating ALG13-CDG has been challenging due to elusive glycosylation defects in patient samples, particularly in blood and fibroblas...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD051647 | Pride
Congenital disorder of glycosylation  metabolomics  single cell rna  proteomics Neurodevelopmental disorder Glycoproteomics Cortical brain organoids 
TranscriptomicsKnockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion
Genome-wide association studies have convincingly implicated several novel genes in susceptibility to schizophrenia and bipolar disorder. The first genome-wide significant association with the broad phenotype of psychosis was with a polymorphism in the ZNF804A gene. However, the biological function(...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-28725 | biostudies-arrayexpress
TranscriptomicsMaternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response.
Maternal immune activation is a risk factor for the development of schizophrenia and autism. Infections during pregnancy activate the mother's immune system and alter the fetal environment with sub-sequence effects of CNS function and behavior in the offspring, but the cellular and molecular links b...
ORGANISM(S): Rattus norvegicus 
2012-07-25 | E-GEOD-34058 | biostudies-arrayexpress
TranscriptomicsArx acts as a key selector gene of the ventral telencephalon mainly through its repression transcriptional activity
The homeobox containing gene Arx is expressed during ventral telencephalon development and it is required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. Its human ortholog is associated with a variety of neur...
ORGANISM(S): Mus musculus 
2010-03-09 | E-GEOD-12956 | biostudies-arrayexpress
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