Cortical organoids

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Sunnybrook Research Institute, Toronto, ON, Canada / Department of Biochemistry, University of Toronto, Toronto, ON, Canada / Department of Biochemistry and Molecular Biology, Alberta Children’s Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada / Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (1)
Synapse Proteomics, Children's Medical Research Insitute, The University of Sydney, Australia (1)

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EVOLUTION OF THE LIPIDOME UNCOVERS EARLY CHANGES IN ADRENOLEUKODYSTROPHY HUMAN CORTICAL AND SPINAL ORGANOIDS

Lipids are critical for the structure, signaling, and metabolism of the central nervous system (CNS), yet their roles during human brain development remain underexplored due to limited tissue availability. X-linked adrenoleukodystrophy (ALD), a peroxisomal disorder caused by ABCD1 mutat...

2025-11-17 | MTBLS12973 | MetaboLights

Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights

Human cortical organoids. Chronic treatment with GSK3 inhibitor CHIR99021. Bulk RNAseq.

Here we used human cortical brain organoids to probe the longitudinal impact of GSK3 inhibition through multiple developmental stages. Chronic GSK3 inhibition increased the proliferation of neural progenitors and caused massive derangement of cortical tissue architecture. Cortical organoids were dif...

ORGANISM(S): Homo sapiens

2020-06-04 | E-MTAB-8325 | biostudies-arrayexpress

RNA-seq of INPP5E mutant cortical organoids against control organoids

Primary cilia act as antennas in cell-cell signalling and are crucial for nervous system development. We explored their role in the development of the human cerebral cortex using organoids defective for the ciliary gene INPP5E. We investigated the transcription profile of control and INPP5ED477N/D47...

ORGANISM(S): Homo sapiens

2022-06-06 | E-MTAB-11437 | biostudies-arrayexpress

Single cell analysis of iPSC-derived cortical organoids in biofunctionalized gelatin hydrogels

Human neural organoid models have become an important tool for studying neurobiology. In this work, we compared Matrigel to an N-cadherin peptide-functionalized gelatin methacryloyl hydrogel (termed GelMA-Cad) for culturing cortical neural organoids. Specifically, we compare five materials: (1) Matr...

ORGANISM(S): Homo sapiens

2024-02-28 | E-MTAB-13828 | biostudies-arrayexpress

Single cell analysis of iPSC-derived cortical organoids in biofunctionalized gelatin hydrogels

ORGANISM(S): Homo sapiens

2024-07-01 | E-MTAB-14203 | biostudies-arrayexpress

RNA-seq of Human Cortical Organoids Treated with Ciprofloxacin versus Untreated Controls

Human cortical organoids (hCOs) were employed to examine the developmental neurotoxic effects of ciprofloxacin (CPFX). Organoids were subjected to chronic exposure to low doses of CPFX for two weeks, while untreated organoids served as controls. Assessments included mitochondrial function, reactive ...

ORGANISM(S): Homo sapiens

2026-03-31 | E-MTAB-16792 | biostudies-arrayexpress

Proteomics characterisation of induced pluripotent stem cells and cortical brain organoids.

A method was developed to reproducibly produce neural retina and cortical brain regions from confluent cultures of stem cells. The spontaneously generated cortical organoids were isolated and cultured in suspension conditions for maturation. Proteomic analysis of both the original induced pluripoten...

ORGANISM(S): Homo sapiens (Human)

2022-05-06 | PXD025933 | Pride

ATM-knockout on total and phosphorylation proteomes of cortical brain organoids

ATM (ataxia telangiectasia mutated) kinase is crucial to a wide range of human developmental disorders and adult/pediatric malignancies. Its mutations are causally tied to ataxia telangiectasia, a multi-systemic congenital disorder mainly affecting brain and blood systems. We generated 4 separate ...

ORGANISM(S): Homo sapiens (Human)

2024-07-25 | PXD041699 | Pride

Phosphorylation proteome proteome atm kinase cortical brain organoids

Modeling Focal Cortical Dysplasia (FCD) using cortical organoids

PRJNA730718 | ENA

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