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UnknownMechanism of cotranslational modification of histones H2A and H4 by MetAP1 and NatD.
Not available
S-EPMC12716425 | biostudies-literature
ProteomicsCUL4A-DDB1-DCAF10 is an n-recognin for Nt-acetylated Src kinases
cotranslational n-terminal modifications such as methionine excision, acetylation, and myristoylation contribute to protein stability, localization and three-dimensional folding. Disruption of these modifcations expose short n-terminal degron motifs that ultimately trigger protein degradation throug...
ORGANISM(S): Homo sapiens (Human) 
2025-12-04 | PXD061095 | Pride
N-t acetylation Sfks N-degron dcaf10 Ubiquitination Nt- myristoylation Cotranslational modifications N-recognin 
ProteomicsSTIC2 selectively binds ribosome-nascent chain complexes in the cotranslational sorting of Arabidopsis thylakoid proteins
Chloroplast-encoded multi-span thylakoid membrane proteins are crucial for photosynthetic complexes, yet the coordination of their biogenesis remains poorly understood. To identify factors that specifically support the cotranslational biogenesis of the reaction center protein D1 of photosystem (PS) ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-08-28 | PXD042896 | Pride
Thylakoid membrane Photosystem ii Arabidopsis Cotranslational targeting Stic2 
ProteomicsThe state transition acetyltransferase GNAT2 interacts with GNAT1 and GNAT3 in independent complexes
The acetylation of amino groups within proteins is one of the major posttranslational modifications (PTMs) in all organisms. N-terminal acetyltransferases (NATs) or lysine acetyltransferases (KATs) catalyze the transfer of the acetyl group from the donor substrate acetyl coenzyme A (Ac-CoA) to the t...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2024-08-19 | PXD044167 | JPOST Repository
ProteomicsCotranslational activity of the GroEL chaperonin
Various proteins in the cell begin to fold during synthesis at the ribosome, many with the assistance of molecular chaperones. While the cotranslational activity of ribosome-associated chaperones and Hsp70 is frequently studied, the role of Hsp60 chaperonins during protein synthesis remains poorly u...
ORGANISM(S): Escherichia coli 
2025-10-14 | PXD054379 | Pride
Groel Xl-ms Rnc 
UnknownNAC guides a ribosomal multienzyme complex for nascent protein processing.
Not available
S-EPMC12039536 | biostudies-literature
UnknownThe dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Not available
S-EPMC10118133 | biostudies-literature
UnknownRibosome-nascent Chain Interaction Regulates N-terminal Protein Modification.
Not available
S-EPMC9126151 | biostudies-literature
UnknownCoordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.
Not available
S-EPMC8682741 | biostudies-literature
UnknownDivergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants.
Not available
S-EPMC10473758 | biostudies-literature
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