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UnknownEfficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: A multi-cohort randomized controlled trial.

Background

The efficacy of the widely used albendazole against the soil-transmitted helminth Trichuris trichiura is limited; yet optimal doses, which may provide increased efficacy, have not been thoroughly investigated to date.

Methods

A randomized-controlled trial was conduct...
S-EPMC7210508 | biostudies-literature
UnknownTrichuriasis in Human Patients from Cote d'Ivoire Caused by Novel Trichuris incognita Species with Low Sensitivity to Albendazole/Ivermectin Combination Treatment.
Albendazole/ivermectin combination therapy is a promising alternative to benzimidazole monotherapy alone for Trichuris trichiura control. We used fecal DNA metabarcoding to genetically characterize Trichuris spp. populations in patient samples from Côte d'Ivoire showing lower (egg reduction rate <70...
S-EPMC11682790 | biostudies-literature
UnknownWidespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections.
Soil-transmitted helminthiases, particularly trichuriasis, affect over 500 million people, mostly in low- and middle-income countries. Traditional diagnostics fail to distinguish between Trichuris species, obscuring transmission patterns and treatment outcomes. Using nanopore-based full-length ITS2 ...
S-EPMC12595021 | biostudies-literature
UnknownModeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura.
Trichuris trichiura is one of four soil-transmitted helminth species that, collectively, are responsible for a considerable public health burden. The World Health Organization recommends preventive chemotherapy as the main intervention to eliminate soil-transmitted helminthiasis as a public health p...
S-EPMC11464734 | biostudies-literature
UnknownAssessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a case-control substudy conducted in Cote d'Ivoire, Lao PDR and Pemba Island, Tanzania.

Background

Infections with soil-transmitted helminths (STHs) may result in chronic inflammatory disorders affecting the human host. The objective of this study was to evaluate Fecal Calprotectin (FC) and Fecal Occult Blood (FOB) in individuals infected and non-infected with STHs to identify ...
S-EPMC7851339 | biostudies-literature
UnknownQuestionnaire-based approach to assess schoolchildren's physical fitness and its potential role in exploring the putative impact of helminth and Plasmodium spp. infections in Cote d'Ivoire.

Background

Disability weights (DWs) are important for estimating burden of disease in terms of disability-adjusted life years. The previous practice of eliciting DWs by expert opinion has been challenged. More recent approaches employed quality of life (QoL) questionnaires to establish patie...
S-EPMC3157450 | biostudies-literature
UnknownAssociations between soil-transmitted helminth infections and physical activity, physical fitness, and cardiovascular disease risk in primary schoolchildren from Gqeberha, South Africa.

Background/aim

School-aged children in low- and middle-income countries carry the highest burden of intestinal helminth infections, such as soil-transmitted helminths (STH). STH infections have been associated with negative consequences for child physical and cognitive development and wellbe...
S-EPMC10575529 | biostudies-literature
UnknownEffect of schistosomiasis and soil-transmitted helminth infections on physical fitness of school children in Cote d'Ivoire.

Background

Schistosomiasis and soil-transmitted helminthiasis are important public health problems in sub-Saharan Africa causing malnutrition, anemia, and retardation of physical and cognitive development. However, the effect of these diseases on physical fitness remains to be determined.
S-EPMC3139653 | biostudies-literature
UnknownBiomarker Detection and Validation for Corneal Involvement in Patients With Acute Infectious Conjunctivitis.

Importance

Infectious conjunctivitis can lead to corneal involvement and result in ocular morbidity. The identification of biomarkers associated with corneal involvement has the potential to improve patient care.

Objective

To identify biomarkers in patients with acute infectious conju...
S-EPMC11327903 | biostudies-literature
UnknownGenomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance.
Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 7...
S-EPMC9715550 | biostudies-literature
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