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TranscriptomicsMolecular crosstalk between hepatocytes and hepatic stellate cells.
Aim of the study was to characterize at a molecular level (changes in transcriptomes) the crosstalk between tumor hepatocytes and activated hepatic stellate cells (HSC) in liver cancer. This was adressed by using a coculture model system of HepaRG cell line (tumor hepatocytes, human), and LX2 cell l...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-32565 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of tumor stroma in human intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The pr...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-45001 | biostudies-arrayexpress
TranscriptomicsStudy of transcriptional effects of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line.
Aim of the study was to characterize at a molecular level (changes in transcriptomes) the effect of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line. This was adressed by using a culture model. The HaCaT cell line (human keratinocytes) was stimulated by MSU (1mg/mL) vs control for 12 h...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-65931 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of liver tissue from lean (WT) and obese (ob/ob) mice following a chronic exposure of low doses of pharmaceuticals
BACKGOUND: Drinking water can be contaminated with pharmaceuticals. However, it is uncertain whether this contamination can have harmful consequences for the liver, especially in the context of obesity. OBJECTIVES: To determine whether chronic, low dose exposure to pharmaceuticals could have deleter...
ORGANISM(S): Mus musculus 
2014-03-04 | E-GEOD-49195 | biostudies-arrayexpress
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