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Novel asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus

How essential asymmetries are built into icosahedral virus to facilitate directional genome egress is unknown. Here we capture the structure and dynamics of disassembly intermediates of an icosahedral virus. We reveal localized RNA density poised for release beneath 5-fold axes on one half of the vi...

ORGANISM(S): Turnip crinkle virus

2025-11-06 | PXD067878 | Pride

Alternate covalent form of platelet αIIbβ3

The αIIbβ3 integrin receptor coordinates platelet adhesion, activation and mechanosensing in thrombosis and haemostasis. Using differential cysteine alkylation and mass spectrometry, we have identified a disulfide bond in the αIIb subunit linking cysteines 490 and 545 that is missing in about one in...

ORGANISM(S): Homo sapiens (Human)

2022-02-17 | PXD025907 | Pride

Αiibβ3 Platelet Disulfide Covalent Integrin

Thioamide-warheads with enhanced cysteine reactivity and specificity for targeted covalent inhibitors

Targeted covalent inhibitors (TCIs) form covalent bond with their target that requires tailored reactive functionalities identified as warheads. Here we present a versatile approach changing carboxamide functions with thioamides that transforms known warheads to softer electrophiles enhancing reacti...

ORGANISM(S): Homo sapiens (Human)

2026-09-07 | PXD054470 | Pride

Warhead Proteomics Cystein Covalent inhibitors

Theoretical studies on anhydride dynamic covalent bond exchange mechanisms.

Not available

S-EPMC12624005 | biostudies-literature

The third orthogonal dynamic covalent bond.

Not available

S-EPMC6014071 | biostudies-literature

Two-colour light activated covalent bond formation.

Not available

S-EPMC9135712 | biostudies-literature