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ProteomicsIntact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies
This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073416 | Pride
Covalent binding Lc-ms Lc-f2-1 Fgfr2 v564f 
TranscriptomicsDNA unmethylome profiling by covalent capture of CpG sites
Here we present an approach for the mapping of unmethylated DNA. Our technique is based on DNA methyltransferase-directed transfer of activated groups (mTAG) and covalent biotin tagging of unmodified CpG sites followed by affinity enrichment and interogation on tiling microarrays or next generation ...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-48994 | biostudies-arrayexpress
GenomicsIdentification of covalent small-molecule inhibitors of STING
Identification of covalent small-molecule inhibitors of STING
PRJNA454500 | ENA
TranscriptomicsDNA unmethylome profiling by covalent capture of CpG sites (microarray)
Here we present an approach for the mapping of unmethylated DNA. Our technique is based on DNA methyltransferase-directed transfer of activated groups (mTAG) and covalent biotin tagging of unmodified CpG sites followed by affinity enrichment and interogation on tiling microarrays or next generation ...
ORGANISM(S): Homo sapiens 
2013-08-27 | E-GEOD-49044 | biostudies-arrayexpress
GenomicsEngineering covalent small molecule–RNA complexes in living cells
Engineering covalent small molecule–RNA complexes in living cells
PRJNA1133002 | ENA
GenomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50622 | biostudies-arrayexpress
GenomicsDevelopment of potent and selective KDM5 covalent inhibitors
Development of potent and selective KDM5 covalent inhibitors
PRJNA486160 | ENA
GenomicsCovalent Targeting of Splicing in T Cells
Covalent Targeting of Splicing in T Cells
PRJNA1171002 | ENA
ProteomicsAlternate covalent form of platelet αIIbβ3
The αIIbβ3 integrin receptor coordinates platelet adhesion, activation and mechanosensing in thrombosis and haemostasis. Using differential cysteine alkylation and mass spectrometry, we have identified a disulfide bond in the αIIb subunit linking cysteines 490 and 545 that is missing in about one in...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025907 | Pride
Αiibβ3 Platelet Disulfide Covalent Integrin 
ProteomicsCovalent allosteric inhibition of AARS1 lactyltransferase
Alanyl-tRNA synthetase 1 (AARS1) was recently identified as a lactyltransferase responsible for protein lactylation, a modification associated with epigenetic regulation and metabolic adaptation. AARS1 catalyzes lysine lactylation via an ATP- and lactate- dependent, but lactyl-CoA-independent mechan...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD076410 | Pride
Lactyltransferase Covalent ligand Aars1 
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