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UnknownThe alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Not available
S-EPMC11093599 | biostudies-literature
GenomicsMus musculus
NPM3 functions as a lactyltransferase in diabetic cardiomyopathy (PRJCA049021)
PRJDB41421 | ENA
UnknownHAT1 functions as a lactyltransferase and mediates RPA1 lactylation to promote DNA repair and radioresistance in lung adenocarcinoma.
Not available
S-EPMC12639135 | biostudies-literature
UnknownHAT1 as a Lactyltransferase to Promote DNA Repair Through RPA1 Lactylation in Glioblastoma.
Not available
S-EPMC12905578 | biostudies-literature
GenomicsHBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. However, the regulatory mechanism and functional consequence of Kla remain to be explored. Here, we report that HBO1 functions as a lysine lactyltransferase to regulate transcription....
ORGANISM(S): Homo sapiens 
2024-01-16 | GSE239656 | GEO
UnknownUnlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation
Not available
S-EPMC12143591 | biostudies-literature
GenomicsACSS2-coupled KAT2A regulates histone H3 lactylation in gene promoter regions and gene expression
We report EGFR activation induces ERK-mediated S267 phosphorylation of acetyl-CoA synthetase 2 (ACSS2) and its subsequent nuclear translocation and complex formation with lysine acetyltransferase 2A (KAT2A).Consequently, KAT2A acts as a lactyltransferase to lactylate histone H3, leading to expressio...
ORGANISM(S): Homo sapiens 
2024-10-01 | GSE278139 | GEO
ProteomicsSILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD051415 | Pride
Hela Lc-msms Hbo1 Kla 
UnknownHBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription.
Not available
S-EPMC11053077 | biostudies-literature
ProteomicsNuclear GTPSCS functions as a lactyl-CoA ligase to promote histone lactylation and glioma progression
Histone lysine lactylation is a physiologically relevant epigenetic pathway that can be stimulated by the Warburg effect and hypoxia-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-CoA, the cofactor for the modification, and how this process is regu...
ORGANISM(S): Homo sapiens (Human) 
2024-12-04 | PXD037672 | Pride
Tumorigenesis Lactylation The warburg effect Histone marks P300 Hypoxia Succinyl-coa synthetase Lactyl-coa ligase Epigenetics 
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