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ProteomicsHistone Kla is regulated by cellular glycolysis
We have identified a new histone modification, which is derived from glycolysis end product, lactate. By SILAC-MS/MS based quantification, and U-13C6 glucose labeling experiments, we demonstrate that histone Kla is regulated by cellular glycolysis pathway
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD014870 | Pride
Human mcf-7 cells silac 
ProteomicsGlobal profiling of lysine lactylation in prostate cancer cells
Lysine lactylation (Kla) is a recently identified post-translational modification derived from lactate that regulates diverse biological processes. Although Kla has been studied in several cancers, its role in prostate cancer (PC) remains unclear. We identified 681 Kla sites across 379 proteins, w...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD063266 | Pride
Human Prostate Post-translational modification 
GenomicsEffects of dexamethasone and KLA on HepG2 gene expression
Effects of dexamethasone and KLA on HepG2 gene expression
PRJNA1168060 | ENA
ProteomicsSILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD051415 | Pride
Hela Lc-msms Hbo1 Kla 
ProteomicsSIRT1/SIRT3 are robust lysine delactylases and SIRT1-mediated delactylation regulates glycolysis
Lysine lactylation (Kla), a newly identified epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, marks a pivotal juncture between metabolic pathways and gene regulation. The discovery of enzymes such as p300 and HDAC1/3 has been pivotal in deciphering the regulatory...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050147 | Pride
Lysine lactylation Protein post-translational modifications Delactylase Proteomics Sirtuins 
UnknownLysine lactylation (Kla) might be a novel therapeutic target for breast cancer.
Not available
S-EPMC10636881 | biostudies-literature
UnknownCoadministration of kla peptide with HPRP-A1 to enhance anticancer activity.
Not available
S-EPMC6839859 | biostudies-literature
GenomicsDynamic profiling of histone Kcr and Kla during neural differentiation in vivo
Dynamic profiling of histone Kcr and Kla during neural differentiation in vivo
PRJNA718305 | ENA
TranscriptomicsEffects of dexamethasone and KLA on HepG2 gene expression
In this study, we exposed HepG2 cells to synthetic glucocorticoid dexamethasone (Dex), Kdo2-Lipid A (KLA), or both (DexKLA) for 24 hours and conducted RNA-seq analysis to investigate the impact of exposures on gene expression. We aimed to elucidate how Dex and KLA disrupt, misregulate, or interfere ...
ORGANISM(S): Homo sapiens 
2025-04-11 | GSE278602 | GEO
UnknownFSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction.
Not available
S-EPMC8385177 | biostudies-literature
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