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UnknownSirtuin 6 is a histone delactylase.
Not available
S-EPMC12664031 | biostudies-literature
ProteomicsSIRT3 acts as delactylase to suppress hepatocellular carcinoma development
Our integrative studies characterized SIRT3 as a delactylase to suppress HCC development, and the activation of SIRT3 might be a promising therapeutic mean for HCC.
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039202 |
GenomicsDelactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
PRJNA1158725 | ENA
GenomicsDelactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer [RNA-seq: glucose free]
Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer [RNA-seq: glucose free]
PRJNA1159744 | ENA
TranscriptomicsDelactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer
Histone lactylation, a novel epigenetic modification, is regulated by the lactate produced by glycolysis. Glycolysis is activated in various cancers, including gastric cancer (GC). However, the molecular mechanism and clinical impact of histone lactylation in GC remain poorly understood. Here, we de...
ORGANISM(S): Homo sapiens 
2026-09-09 | GSE276703 | GEO
TranscriptomicsDelactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer [RNA-seq: glucose free]
Histone lactylation, a novel epigenetic modification, is regulated by the lactate produced by glycolysis. Glycolysis is activated in various cancers, including gastric cancer (GC). However, the molecular mechanism and clinical impact of histone lactylation in GC remain poorly understood. Here, we de...
ORGANISM(S): Homo sapiens 
2026-09-11 | GSE276926 | GEO
UnknownSIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells.
Not available
S-EPMC9174446 | biostudies-literature
UnknownDelactylase effects of SIRT3 on a positive feedback loop involving the RUNX1-glycolysis-histone lactylation in diabetic kidney disease.
Not available
S-EPMC12905586 | biostudies-literature
ProteomicsSIRT3 functions as an eraser of histone H3K9 lactylation to modulate transcription for inhibiting the progression of esophageal cancer
As a novel post-translational modification of histone derived from lactate, lysine lactylation (Kla) links lactate metabolism to epigenetic regulation, playing a role in modulation of gene expression in tumor and immune microenvironment. Evidence so far indicates that HDAC1-3 can catalyze the remova...
ORGANISM(S): Homo Sapiens 
2025-02-27 | PXD061251 |
TranscriptomicsPARK7-Mediated Delactylation of SF3B Reprograms RNA Splicing to Attenuate Fibrosis and Promote Anti-Tumor Immunity
Lactylation, an emerging post-translational modification, plays a crucial role in epigenetic regulation and tumorigenesis. However, the key enzymes governing lactylation, including writer, eraser and reader, and their effects on tumors remain poorly characterized. Here, using lactylome analysis and ...
ORGANISM(S): Mus musculus 
2026-05-28 | GSE333386 | GEO
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