Sort   by:  
 Page size 
TranscriptomicsEffects of the JADE-HBO1 complex on gene expression
We find that 499 genes are up-regulated and 457 are down-regulated in response to over-expression of JADE1, while 397 genes are up-regulated and 385 are down-regulated after HBO1 knock-down. For each condition - HBO1 siRNA treatment or JADE1 over-expression - two biological replicates were analyzed ...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33220 | biostudies-arrayexpress
GenomicsGenome-wide map of HBO1 in cancer derived human cell line
We used ChIP-seq technology in order to map chromatin binding sites of the HBO1 MYST complex in the RKO cell line. We obtained a significant enrichment of the HBO1 signal right after TSS regions of genes and also In the proximal promoter region, with no signal on TSS. This enrichment also correlates...
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33007 | biostudies-arrayexpress
TranscriptomicsConserved molecular interactions within MYST-ING acetyltransferase complexes that regulate cell proliferation
This SuperSeries is composed of the following subset Series: GSE33007: Genome-wide map of HBO1 in cancer derived human cell line GSE33220: Effects of the JADE-HBO1 complex on gene expression Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-03-15 | E-GEOD-33221 | biostudies-arrayexpress
ProteomicsLabel-free DDA proteome for identifying the interacting proteins of HBO1
HBO1 is an important transcriptional activator for organism to respond to natural stress. Here, we performed IP-MS for determining the interacting proteins of HBO1 under stimulation of BHB.
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051692 | Pride
Human Label-free Ip-ms Hbo1 
Proteomics,MultiomicsFeng_P120_VS1_BRPF3_HBO1_complex
This submission contains the mass spectrometry files for the manuscript by Feng et al. that describes the characterization of a protein complex containing BRPF3 and HBO1 in the regulation of DNA replication origins. This submission contains 3 IDA files for the following baits: empty 3XFLAG control, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-11-19 | MSV000078943 | MassIVE
ProteomicsHBO1 Catalyzes Lysine Benzoylation in Mammalian Cells
Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely unknown, hindering further functional studies. Here we ident...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034187 | Pride
Lysine benzoylation Post-translational modification Hbo1 Transferase 
GenomicsChIP-seq of MYST acetyltransferases
Histone acetyltransferases (HAT) assemble into multisubunit complexes in order to target distinct lysine residues on nucleosomal histones. Here, we characterize native HAT complexes assembled by the BRPF-family of scaffold proteins. Their PHD-ZnKnuckle-PHD domain is essential for binding chromatin...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-47190 | biostudies-arrayexpress
ProteomicsSILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells
Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051668 | Pride
Human Cervical cancer Kbhb Hbo1 Lc-ms/ms 
TranscriptomicsJade1 ChIP-chip on ENCODE Tiling array
Several MYST-family histone acetyltransferase (HAT) enzymes associate with specific ING tumor suppressor proteins. ING complexes containing the HBO1 HAT protein are the major source of histone H4 acetylation in vivo and have been shown to play critical roles in gene regulation and DNA replication. H...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14309 | biostudies-arrayexpress
ProteomicsProteome analysis of affinity-purified protein co-precipitates
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
ORGANISM(S): Homo Sapiens (human) 
2021-08-31 | PXD027400 | JPOST Repository
Sort   by:  
 Page size