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ProteomicsKbhb proteome in 293 cells
We performed an global Kbhb proteome screening and identified ~3000 Kbhb substrate.
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012328 | Pride
Kbhb Ptms Proteome 
ProteomicsSILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells
Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051668 | Pride
Human Cervical cancer Kbhb Hbo1 Lc-ms/ms 
Proteomicsβ-Hydroxybutyrylation in Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM) is characterized by metabolic remodeling and energetic stress independent of coronary artery disease. Increased reliance on fatty acid and ketone body metabolism has been observed in DCM, but the regulatory mechanisms linking altered substrate utilization to myocardial ...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD066713 | Pride
Diabetic cardiomyopathy  β-hydroxybutyrylation (kbhb)  metabolic remodeling  ketone body metabolism  mitochondrial regulation 
UnknownMachine learning-based identification of kbhb-affected tumor cell subsets as prognostic and therapeutic targets in breast cancer.
Not available
S-EPMC12802299 | biostudies-literature
ProteomicsIdentification and profiling of dynamic changes of site-specific histone acylations in HEK293T cells under metabolites treatment
1. Systematic survey of PTM site and stoichiometry on histone proteins has been lagged behind due to the lack of efficient quantitative peptide comparison methodology on histone proteins. Our quantitative mass spectrometry-based proteomics approach, Site-Profiling, used SILAC-based peptide ratio ana...
ORGANISM(S): Homo sapiens (Human) 
2023-03-06 | PXD029508 | Pride
Hek293t Histone acylation Site-specific Lc-ms/ms 
Genomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [ATAC-seq]
β-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [ATAC-seq]
PRJNA1251654 | ENA
Genomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [ChIP-seq]
β-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [ChIP-seq]
PRJNA1251655 | ENA
Genomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [RNA-seq]
β-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [RNA-seq]
PRJNA1251656 | ENA
ProteomicsMouse Liver Lysine β-hydroxybutyrylome
Characterization of the lysine β-hydroxybutyrylome, proteome-wide, will start to define its cellular targets and enable investigation of its impact under ketogenesis. Here, we show the induction of global protein Kbhb in the liver. We identified 891 sites of Kbhb within 267 proteins belonging to mac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016654 | Pride
Mouse Liver Lysine β-hydroxybutyrylation 
Genomicsβ-Hydroxybutyrate Boosts Plant Immunity through Enhanced histone Kbhb Levels and Gene Expression Regulation [ChIP-seq]
We demonstrated functional differences between H3K9bhb and the well-studied H3K9ac, particularly in regulating immune-response genes in rice. Moreover, we show that exogenous application of β-hydroxybutyrate enhances disease resistance in rice by inducing H3K9bhb deposition and stimulating the expre...
ORGANISM(S): Oryza sativa Japonica Group 
2025-06-07 | GSE294828 | GEO
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