Lc-f2-1 - OmicsDI

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Proteomics (36)
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Acidithiobacillus ferrooxidans ATCC 53993 (35)
Aerococcus urinae NBRC 15544 = CCUG 36881 (35)
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pride (35)
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Aortic valve stenosis (2)
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Mass Spectrometry (35)
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MaXis (1)
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CHEBI ID

CHEBI:183372 (1)
CHEBI:192601 (1)
CHEBI:228797 (1)
CHEBI:165341 (1)
CHEBI:190537 (1)
CHEBI:26756 (1)
CHEBI:32818 (1)
CHEBI:192665 (1)
CHEBI:72381 (1)
CHEBI:59750 (1)
CHEBI:183334 (1)
CHEBI:228796 (1)
CHEBI:75815 (1)
CHEBI:228795 (1)
CHEBI:189466 (1)
CHEBI:228794 (1)
CHEBI:190595 (1)
CHEBI:167228 (1)
CHEBI:64023 (1)
CHEBI:176838 (1)
CHEBI:138537 (1)
CHEBI:194705 (1)
CHEBI:95050 (1)
CHEBI:32811 (1)
CHEBI:228793 (1)
CHEBI:194253 (1)
CHEBI:183496 (1)
CHEBI:228792 (1)
CHEBI:12256 (1)
CHEBI:73989 (1)

Metabolite Name

6-phospho-D-glucono-1,5-lactone (1)
3'-Adenosine monophosphate (3'-AMP) (1)
J147 (1)
1-methyl-N-(3-methyl-5-cinnolinyl)-1H-imidazole-4-sulfonamide (1)
6-anilino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (1)
Ip7G (1)
L-Threonic acid Calcium Salt (1)
Myricetin 3-O-beta-D-galactopyranoside (1)
Sodium Dehydrocholate (1)
4-(beta-D-Glucopyranosyloxy)-2-methylenebutanoic acid (1)
Dl-2-Amino-3-phosphonopropionic acid (1)
17 alpha-Ethynylestradiol (1)
PE O-18:1_20:4 (1)
Hydroxytriazolam (1)
LPE 19:1 (1)
Kinetin 9-riboside (1)
4-Hydroxy-L-Glutamic Acid (1)
PE 16:0_16:1 (1)
N1-(6-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)-4-nitrobenzamide (1)
Alanyltyrosine (1)
(±)9-HpODE (1)
PE 16:0_17:1 (1)
7-hydroxy-3-phenyl-4H-chromen-4-one (1)
Sulfamethoxazole hydroxylamine (1)
5-Methoxyindole-3-Carbaldehyde (1)
2-[6-(1H-benzo[d]imidazol-2-yl)-2-pyridyl]-1H-benzo[d]imidazole (1)
Oxoadipic Acid (1)
N-acetyl-D-glucosamine (1)
1-Caffeoylquinic Acid (1)
Beta-Estradiol 17-Acetate (1)

First Public Date

2022 (1)

Study type

RNA-seq of coding RNA (1)

Release Date

2023 (4)
2021 (3)
2019 (2)
2015 (1)
2024 (1)
2022 (1)
2020 (1)

Lab affiliation

Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany Frankfurt Cancer Institute, Frankfurt am Main, Germany Cardio-Pulmonary Institute, Frankfurt am Main, Germany (3)
Parasitology Laboratory, Institute of Natural Resources and Agrobiology (IRNASA, CSIC). Cordel de Merinas, 40-52, 37008 Salamanca, Spain. (2)
Biomedical & Life Sciences, Lancaster University UK (1)
Cedars-Sinai Medical Center, Heart Institute Advanced Clinical Biosystems Research Institute (1)
Cell Signaling and Immunology, School of Life Science, University of Dundee, Dundee. United Kingdom (1)
Clinical Protein Science & Imaging, Department of Clinical Sciences (Lund), Department of Biomedical Engineering, Lund University, Lund, Sweden. (1)
Department of Immunology, College of Basic Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, China. (1)
Department of environmental science and policy, University of Milan, Milan, Italy (1)
Director of Carnegie Mass Spectrometry Facility, Carnegie Institution for Science, Stanford (1)
Goethe University, Institute for Biochemistry II, Frankfurt am Main (1)
Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Henan 450052, China (1)
Institute for Microbiology, Friedrich Schiller University, Jena, Germany and Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product and Infection Biology (HKI), Hans Knöll Institute, Jena, Germany (1)
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain (1)
Institute for biochemistry II, ER quality control (1)
Institute of Biochemistry II, Goethe University Hospital Frankfurt/Main, Germany (1)
Institute of Molecular Systems Medicine, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany. The Center for Functional Proteomics, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany. Frankfurt Cancer Institute, Frankfurt am Main, Germany. Cardio-Pulmonary Institute, Frankfurt am Main, Germany. (1)
Kings College University London (1)
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) (1)
Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, The University of Manchester (1)
Manchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, The University of Manchester, UK (1)
Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute Jena (1)
Monash University, Clayton, Australia (1)
Osnabrueck University Department of Biology/Chemistry Bioanalytical chemistry section (1)
Principle Investigator Proteomics (1)
Regeneron Proteomics and Biomarkers (1)
SULFAGING group; Leibniz Institute for Analytica Sciences - ISAS - eV. Dortmund, GERMANY (1)
School of Pharmacy, Hangzhou Medical College, Hangzhou 310014, Zhejiang, 8 China (1)
Sulfaging group Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. Bunsen-Kirchhoff-Straße 11, 44139 Dortmund Germany (1)
Universitat de Barcelona. Parc Cientific de Barcelona. Proteomics Lab. (1)
University of Dundee, School of Life Sciences (1)

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Intact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies

This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...

ORGANISM(S): Homo sapiens (Human)

2026-09-14 | PXD073416 | Pride