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MetabolomicsProphylactic and therapeutic itaconate treatment alleviates COVID-19-associated lung injury

Although itaconate demonstrates anti-inflammatory and antimicrobial properties as an immunomodulatory metabolite, the therapeutic potential and mechanistic basis of vaccine-induced or prophylactic itaconate administration in COVID-19 intervention remains underexplored. Our studies reveal that int...

2025-08-06 | MTBLS12827 | MetaboLights
TranscriptomicsAtherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells
Single-cell RNA sequencing revealed a dysregulated myeloid immune response with hyperinflammatory and immunosuppressive features in patients with ASCVD and moderate COVID-19. Assay for Transposase-Accessible Chromatin sequencing and in-vitro experiments with isolated monocytes infected with SARS-CoV...
ORGANISM(S): Homo sapiens 
2025-01-15 | E-MTAB-16472 | biostudies-arrayexpress
MetabolomicsSerum NMR profiling reveals differential alterations in the lipoproteome induced by Pfizer-BioNTech vaccine in COVID-19–recovered subjects and naïve subjects
Not available
ORGANISM(S): Homo sapiens 
ST002086 | MetabolomicsWorkbench
ProteomicsSerum proteomics covid-19 vaccine
In the last two years, the coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a scientific and social challenge worldwide. Vaccines have been the most effective intervention for reducing virus transmission and disease severity. ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031969 | Pride
Covid-19  proteomic  vaccine  immunology  biomarker 
ModelsMukandavire2020 - SEIR model of early COVID-19 transmission in South Africa
The emergence and fast global spread of COVID-19 has presented one of the greatest public health challenges in modern times with no proven cure or vaccine. Africa is still early in this epidemic, therefore the extent of disease severity is not yet clear. We used a mathematical model to fit to the ob...
2024-09-02 | BIOMD0000000978 | BioModels
COVID-19 
GenomicsInduction of trained immunity by influenza vaccine: impact on COVID-19
Cross-protective effects of certain vaccines against heterologous infections have been reported, and long-term boosting of innate immunity (also termed trained immunity) has been proposed as the underlying mechanism. Several epidemiological studies suggested cross-protection between influenza vaccin...
EGAS00001005446 | EGA
2019 novel coronavirus infection 2019-nCoV infection coronavirus disease 2019 COVID-19 SARS-coronavirus 2 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 
TranscriptomicsSingle cell RNA, BCR and CITE-Seq of longitudinal COVID-19 patients
6 patients with severe COVID-19 were followed longitudinally during hospitalization and up to 1 year after infection, when they also received a vaccine. For each time point and patient, PBMCs were collected and split into 3 pools: 1/3 was sequenced straight; from 1/3 of the samples B cells were enri...
ORGANISM(S): Homo sapiens 
2022-12-06 | E-MTAB-12392 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA and B cell receptor profiling of B cell response to SARS-CoV-2 vaccination
We generated single-cell transcriptomic and BCR sequencing data of B cells from peripheral blood samples taken from a SARS-CoV-2-antigen-naive cohort being vaccinated with the SARS-CoV-2 mRNA-1273 vaccine. Blood samples were collected at the baseline timepoint D-1 (i.e. one day prior to the initial ...
ORGANISM(S): Homo sapiens 
2026-05-08 | E-MTAB-16531 | biostudies-arrayexpress
ModelsSarkar2020 - SAIR model of COVID-19 transmission with quarantine measures in India
In India, 100,340 confirmed cases and 3155 confirmed deaths due to COVID-19 were reported as of May 18, 2020. Due to absence of specific vaccine or therapy, non-pharmacological interventions including so- cial distancing, contact tracing are essential to end the worldwide COVID-19. We propose a math...
2024-09-02 | BIOMD0000000977 | BioModels
COVID-19 
ModelsBertozzi2020 - SIR model of scenarios of COVID-19 spread in CA and NY
The coronavirus disease 2019 (COVID-19) pandemic has placed epidemic modeling at the forefront of worldwide public policy making. Nonetheless, modeling and forecasting the spread of COVID-19 remains a challenge. Here, we detail three regional scale models for forecasting and assessing the course of ...
2024-09-02 | BIOMD0000000956 | BioModels
COVID-19 
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