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MetabolomicsPREDICT: untargeted metabolomic profiling in a Brassica napus (canola) breeding population by GC-MS

Genome-wide association studies (GWAS) identified thousands of genetic loci associated with complex plant traits, including many traits of agronomical importance. However, functional interpretation of GWAS results remains challenging because of large candidate regions due to linkage disequilibriu...

2023-11-20 | MTBLS8056 | MetaboLights
TranscriptomicsCOX-2 overexpression in a conditional KrasG12D mouse model
Pancreatic ductal cells and preneoplastic lesions derived from wild type, Keratin 5 COX-2, P48Cretg/wt K-RasG12D/wt and K5 COX-2 P48Cretg/wt K-RasG12D/wt mouse genotypes were laser capture microdissected. Total RNA was isolated and analysed with Illumuna Sentrix 8 chips.
ORGANISM(S): Mus musculus 
2019-06-24 | E-MTAB-2688 | biostudies-arrayexpress
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
TranscriptomicsIdentification of miR-181 target genes and a common prognostic gene signature in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30258 | biostudies-arrayexpress
ProteomicsA sEH/COX-2 Dual Inhibitor PTUPB Reduces Endothelium-to-Mesenchymal Transition and Improves Doxorubicin-induced Vascular and Cardiac Toxicity
Doxorubicin (DOX) is an effective anthracycline agent used to combat many neoplastic diseases. However, DOX causes cardiovascular toxicity in juvenile and young adult cancer survivors that can lead to future cardiomyopathy. Thus, it is essential to address the cardiovascular toxicity caused by DOX t...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-06-25 | PXD065109 | Pride
Zebrafish Whole protein Doxorubicin Soluble epoxide hydrolase 
UnknownPrognostic Factors of AL-PCMM and AL-MM: A Single-Center Retrospective Study.
Not available
S-EPMC8964324 | biostudies-literature
TranscriptomicsTP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Background: Gene expression profiling of breast carcinomas has increased our understanding of the heterogeneous biology of this disease and promises to impact clinical care. The aim of this study was to evaluate the prognostic value of gene expression-based classification along with established prog...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-40954 | biostudies-arrayexpress
TranscriptomicsIdentification of prognostic gene signatures in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30285 | biostudies-arrayexpress
ProteomicsProteomic analysis of Viscozyme® L and its major enzyme components for pectic substrate degradation
Enzymatic degradation of plant biomass requires the coordinated action of various enzymes. In this study, the production of reducing sugars from pectic substrates and sugar beet pulp (SBP) was investigated and compared using commercial enzyme preparations, including M2, pectinase (E1) from Aspergill...
ORGANISM(S): Aspergillus aculeatus ATCC 16872 
2024-04-09 | PXD045553 | Pride
Sugar beet pulp Carbohydrate-active enzymes Viscozyme l Aspergillus aculeatus Cazyme 
TranscriptomicsMultilineage dysplasia does not influence prognosis in patients with CEBPA mutated AML supporting the WHO proposal to classify these patients as a unique entity
By WHO 2008, CEBPA-mutated AML became a provisional subentity, but it remains to be clarified how CEBPAmut AML with multilineage dysplasia (MLD; ?50% dysplastic cells in 2-3 lineages) but no other MDS-related feature should be classified. We investigated 108 CEBPAmut AML (15.7-87.6 years) for the im...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-33223 | biostudies-arrayexpress
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