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ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
GenomicsGene plofiles of hepatic macrophages expressing mPGES-1.
Gene plofiles of hepatic macrophages expressing mPGES-1.
PRJNA421421 | ENA
GenomicsImpact of mPGES-1 on the resolution of zymosan-induced peritonitis in mice
Impact of mPGES-1 on the resolution of zymosan-induced peritonitis in mice
PRJNA690115 | ENA
TranscriptomicsImpact of mPGES-1 on the resolution of zymosan-induced peritonitis in mice
Despite the progress to understand inflammatory reactions, mechanisms causing their resolution remain poorly understood. Prostanoids, especially prostaglandin E2 (PGE2), are well characterized mediators of inflammation. PGE2 is produced in an inducible manner in macrophages (Mf) by microsomal PGE2-s...
ORGANISM(S): Mus musculus 
2021-02-10 | GSE164364 | GEO
TranscriptomicsExpression data of mouse preoptic region 5 h after LPS-administration comparing wt and mPGES-1 KO mice.
WT mice and mPGES-1 KO mice were treated with 120 mikrogram/kg LPS and sacrificed 5 h later. The preoptic region was dissected by LCM and analyzed using GeneChip Mouse Genome 430 2.0 arrays (Affymetrix). Groups: WT LPS-treated versus mPGES-1 KO LPS-treated mice.
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-43181 | biostudies-arrayexpress
ProteomicsGlobal characterization of miR-574-5p decoy to CUGBP1 in human lung cancer using a mass spectrometry proteomics approach
We aimed to characterize decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1 mechanism in A549 lung cancer cells. We identified several new canonical targets of CUGBP1 but those were not regulated by miR-574-5p via the decoy mechanism. This can be explained by the localization of CUG...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016803 | Pride
Cugbp1 Mir-574-5p Human Lung cancer Mpges-1 
UnknownAnalgesic effects of a highly selective mPGES-1 inhibitor.
Not available
S-EPMC9971260 | biostudies-literature
UnknownSelective inhibitors of human mPGES-1 from structure-based computational screening.
Not available
S-EPMC5586502 | biostudies-literature
UnknownNovel human mPGES-1 inhibitors identified through structure-based virtual screening.
Not available
S-EPMC3183289 | biostudies-literature
UnknownmPGES-1 deletion impairs diuretic response to acute water loading.
Not available
S-EPMC2681360 | biostudies-literature
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