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TranscriptomicsRNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
CUG-binding protein 1 (CUGBP1) and muscleblind-like 1 (MBNL1) are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. We extensively determined RNA-binding sites of CUGBP1 and MBNL1 to investigate their roles in RNA processing. We also analyzed...
ORGANISM(S): Mus musculus 
2012-01-04 | E-MTAB-414 | biostudies-arrayexpress
TranscriptomicsmRNA immunoprecipitated with CUGBP1 in C2C12
Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA abundance. Moreover, just as transcription fact...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21235 | biostudies-arrayexpress
TranscriptomicsExon array analysis in the mouse myoblast cell line, C2C12 cells treated with control-, Cugbp1- or Mbnl1-siRNA
CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. Using HITS-CLIP anlysis, we found CUGBP1 and MBNL1 preferentially bind to alternatively spliced introns and exons, as well as to the 3' UTRs. To analyze more directly the...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-29990 | biostudies-arrayexpress
TranscriptomicsExpression profiles of primary cortical neurons after knocking down Cugbp1
To clarify the functional properties of Cugbp1, we established the differentially expressed alternative exons in Cugbp1-silenced primary cortical neurons by using exon-sensitive microarray technology. We analyzed total RNA of primary motor neuron infected with lentivirus expressing shRNA against mou...
ORGANISM(S): Mus musculus 
2013-04-18 | E-GEOD-46147 | biostudies-arrayexpress
ProteomicsGlobal characterization of miR-574-5p decoy to CUGBP1 in human lung cancer using a mass spectrometry proteomics approach
We aimed to characterize decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1 mechanism in A549 lung cancer cells. We identified several new canonical targets of CUGBP1 but those were not regulated by miR-574-5p via the decoy mechanism. This can be explained by the localization of CUG...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016803 | Pride
Cugbp1 Mir-574-5p Human Lung cancer Mpges-1 
TranscriptomicsSystematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells
This SuperSeries is composed of the following subset Series: GSE21233: Expression data from C2C12 mouse myoblast with treatment actinomycin D GSE21235: mRNA immunoprecipitated with CUGBP1 in C2C12 Refer to individual Series
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21236 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation to identify CUG-BP1/EDEN-BP target mRNAs in Xenopus tropicalis eggs
Identification of RNA bound to the RNA-binding protein CUGBP1/EDENBP in Xenopus tropicalis eggs.
ORGANISM(S): Xenopus tropicalis 
2008-02-21 | E-MEXP-1466 | biostudies-arrayexpress
TranscriptomicsmRNA decay analysis in the mouse myoblast cell line, C2C12 cells treated with conrtol-, Cugbp1- or Mbnl1-siRNA
CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally associated with myotonic dystrophy type 1. Using HITS-CLIP anlysis, we found CUGBP1 and MBNL1 preferentially bind to alternatively spliced introns and exons, as well as to the 3' UTRs. To analyze more directly the ...
ORGANISM(S): Mus musculus 
2012-01-03 | E-GEOD-27583 | biostudies-arrayexpress
ProteomicsLC-MSMS validation of LtpM-mediated O-Glc modification of purified LtpM, CUGBP1, PCBP1 and PCBP2
Validation of LtpM autoglucosylation; validation of the identified O-Glc-modified proteins (CUGBP1, PCBP1 and PCBP2)
ORGANISM(S): Legionella pneumophila Homo sapiens (Human) 
2025-07-14 | PXD058433 | Pride
Ltpm Lc-msms 
GenomicsRNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
RNA CLIP-seq for Cugbp1, Mbnl1 and Ptbp1 in mouse C2C12 myoblasts
PRJEB2614 | ENA
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