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TranscriptomicsTranscription profiling of mouse conditional knock out of beta-catenin by K19-CRE at E7.5
expression profile of conditional knock out of beta-catenin by K19-CRE at E7.5. Tested a wild type with two alleles of beta-catenin, a heterzyote with one deleted allele and the conditional null in the domain on cytokeratin 19 driven CRE expression
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse kideney FROM beta catenin deficient animals vs controls AT E12.5
We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Experiment Overall Design: A comparison was made between triplicate samples of E12.5 kidneys from either no...
ORGANISM(S): Mus musculus 
2008-04-04 | E-GEOD-9629 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse nmyc misexpression in lung (gain of function)
Understanding how lung progenitor cells balance; proliferation against differentiation is relevant to clinical; disorders such as bronchopulmonary dysplasia of; premature babies and lung cancer. Previous studies have; established that lung development is severely disrupted in; mouse mutants with red...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6077 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wildtype lungs vs. lung hypomorphic for nmyc
comparison of expression of wildtype lungs and lungs with hypomorphic expression of nmyc. the lungs were pooled from several biological samples. The hypomorphoic mutant was orignally published in Moens CB et al [PMID: 1577267]. this is part of a larger collection of data comparing nmyc misexpression...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6079 | biostudies-arrayexpress
TranscriptomicsEarly mouse embryo development
Expression profiling of mouse embryos at E2.5, E3.5, E4.25, E4.5, E5.5 E6.0 to identify genes regulated during development of the ICM (inner cell mass), TE (Trophectoderm) and PrE (Primative endoderm) Keywords: development dupicate analysis of time points
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8339 | biostudies-arrayexpress
TranscriptomicsStabilization of ß-catenin during murine Kidney Development
We define a pathogenic role for a ß-catenin-activated genetic pathway in murine renal dysplasia. Cre-mediated stabilization of ß-catenin in the ureteric cell lineage prior to the onset of kidney development increased ß-catenin levels and caused renal aplasia or severe hypodysplasia. A genome-wide an...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-20325 | biostudies-arrayexpress
UnknownGenome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
Not available
S-EPMC4879713 | biostudies-literature
TranscriptomicsDifferentiation time course of trophoblast stem cells
To characterized the changes in gene expression during the differentiation of TS cells. TS cells can be derived from two time point during embryogenesis, cell lines tested were from each of these time points. Keywords: time course TS cells derived from either E3.5 or E6.5 embryos were differentiate...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12985 | biostudies-arrayexpress
TranscriptomicsGata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development
The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcri...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12999 | biostudies-arrayexpress
TranscriptomicsExpression of Cdx2 or Gata3 in R1 mouse embryonic stem cells
To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells. Keywords: gene expression a fusion construct of either Cdx2 or Gata3 and the tamoxif...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12986 | biostudies-arrayexpress
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