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UnknownCardiovascular Disease Incidence and Cardiovascular Health Among Diverse Women With Breast and Gynecologic Cancers.

Objectives

To examine if racial differences in cardiovascular health (CVH) are associated with cardiovascular disease (CVD) disparities among women with breast and gynecologic cancers.

Sample & setting

The sample consisted of 252 Black women and 93 White women without a self-repor...
S-EPMC11350631 | biostudies-literature
UnknownSmall-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.

Background and purpose

An up-regulation of COX-2 in malignant gliomas causes excessive synthesis of PGE2 , which is thought to facilitate brain tumour growth and invasion. However, which downstream PGE2 receptor subtype (i.e., EP1 -EP4 ) directly c...
S-EPMC6514294 | biostudies-literature
UnknownLong-term survival advantage and prognostic factors associated with intraperitoneal chemotherapy treatment in advanced ovarian cancer: a gynecologic oncology group study.

Purpose

To determine long-term survival and associated prognostic factors after intraperitoneal (IP) chemotherapy in patients with advanced ovarian cancer.

Patients and methods

Data from Gynecologic Oncology Group protocols 114 and 172 were retrospectively analyzed. Cox proportional h...
S-EPMC4404424 | biostudies-literature
UnknownInhibition of the RNA Regulator HuR Mitigates Spinal Cord Injury by Potently Suppressing Post-Injury Neuroinflammation.
Neuroinflammation is a major driver of secondary tissue damage after spinal cord injury (SCI). Within minutes after SCI, activated microglia and astrocytes produce proinflammatory mediators such as TNF-α, IL-6, iNOS, and COX-2 which induce tissue injury through cytotoxicity, vascular hyperpermeabili...
S-EPMC12046946 | biostudies-literature
UnknownBayesian Adaptive Randomization Trial of Passive Scattering Proton Therapy and Intensity-Modulated Photon Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer.
Purpose This randomized trial compared outcomes of passive scattering proton therapy (PSPT) versus intensity-modulated (photon) radiotherapy (IMRT), both with concurrent chemotherapy, for inoperable non-small-cell lung cancer (NSCLC). We hypothesized that PSPT exposes less lung tissue to radiation t...
S-EPMC6008104 | biostudies-literature
UnknownCorticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study.

Purpose

To determine clinical predictors associated with corticosteroid administration and its association with ICU mortality in critically ill patients with severe influenza pneumonia.

Methods

Secondary analysis of a prospective cohort study of critically ill patients with confirmed ...
S-EPMC7095489 | biostudies-literature
UnknownGenomic Risk Prediction for Breast Cancer in Older Women.
Genomic risk prediction models for breast cancer (BC) have been predominantly developed with data from women aged 40-69 years. Prospective studies of older women aged ≥70 years have been limited. We assessed the effect of a 313-variant polygenic risk score (PRS) for BC in 6339 older women aged ≥70 y...
S-EPMC8305131 | biostudies-literature
UnknownInterim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test.

Background

A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two cl...
S-EPMC5576286 | biostudies-literature
UnknownCommunity-Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV.
Background Hospitalization with community-acquired pneumonia (CAP) is associated with an increased risk of cardiovascular disease (CVD) events in patients uninfected with HIV. We evaluated whether people living with HIV (PLWH) have a higher risk of CVD or mortality than individuals uninfected with H...
S-EPMC7763776 | biostudies-literature
UnknownProlonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia.

Objective

The purpose of this study was to estimate the time to recovery of command-following and associations between hypoxemia with time to recovery of command-following.

Methods

In this multicenter, retrospective, cohort study during the initial surge of the United States' pandemic...
S-EPMC9082460 | biostudies-literature
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