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TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-07-04 | E-GEOD-11696 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2008-08-08 | E-GEOD-12379 | biostudies-arrayexpress
TranscriptomicsComparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12381 | biostudies-arrayexpress
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12380 | biostudies-arrayexpress
TranscriptomicsWT macrophage response to transfected bacterial ligands
Transcriptional profiling of WT macrophages transfected with L. monocytogenes genomic DNA, synthetic MDP, or both Keywords: Ligand comparison. Experiment in WT background, with different combinations of bacterial ligands. Multiple biological replicates (see array names), with one replicate per arra...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8103 | biostudies-arrayexpress
TranscriptomicsWT and myd88-/- macrophage response to WT and hly- L. monocytogenes
Transcriptional profiling of WT and myd88-/- macrophages infected with WT and hly- L. monocytogenes for 30, 60, 120, or 180 minutes Keywords: Timecourse, cell type comparison, bacteria strain comparison. Timecourse experiment in different genetic backgrounds, with both WT and mutant bacteria. Multi...
ORGANISM(S): Mus musculus 
2007-12-31 | E-GEOD-8100 | biostudies-arrayexpress
TranscriptomicsWT and irf3-/- macrophage response to WT L. monocytogenes
Transcriptional profiling of WT and irf3-/- macrophages infected with WT L. monocytogenes for 180 minutes Keywords: Cell type comparison. Experiment in different genetic backgrounds, with WT bacteria. Multiple biological replicates (see array names), with one replicate per array.
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8101 | biostudies-arrayexpress
TranscriptomicsWT macrophage response to WT L. monocytogenes, with or without CAPE treatment
Transcriptional profiling of WT macrophages infected with WT L. monocytogenes for 180 minutes, with or without CAPE treatment Keywords: Drug comparison. Experiment in WT background, with WT bacteria, with or without drug treatment. Multiple biological replicates (see array names), with one replicat...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8102 | biostudies-arrayexpress
TranscriptomicsPrimary macrophage response to L. monocytogenes and bacteria-derived ligands
Transcriptional profiling of macrophages (of various genetic backgrounds) infected with L. monocytogenes or transfected with purified ligands Keywords: Timecourse, cell type comparison, bacteria strain comparison, drug comparison, ligand comparison. Timecourse experiment in different genetic backgro...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-8104 | biostudies-arrayexpress
ProteomicsCeragenins and antimicrobial peptides kill bacteria through distinct mechanisms
Ceragenins are a family of synthetic amphipathic molecules designed to mimic the properties of naturally-occurring cationic antimicrobial peptides (CAMPs). Although ceragenins have potent antimicrobial activity, whether their mode of action is similar to that of CAMPs has remained elusive. Here we r...
ORGANISM(S): Escherichia coli 
2022-01-10 | PXD022149 | Pride
Antibiotics Gram-negative Mycobacteria Gram-positive Csa 
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