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TranscriptomicsMicroarray expression data from human renal mesangial cells (HMC) treated with a Cyclosporine A (CsA) time course.
HMCs were treated with CsA (4.2 M-BM-5M) for 0 12 and 48 hours. To exmaine global gene changes in the renal mesangium following CsA treatment in order to identify novel contributors to CsA-induced renal dysfunction Microarray analysis was used to identify novel mechanisms of CsA nephrotoxicity in th...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30952 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of FCR3 P. falciparum parasites phenotypicaly selected for adhesion on CSA or CD36
Comparison of FCR3 P. falciparum parasites phenotypicaly selected for adhesion on CSA or CD36.
ORGANISM(S): Plasmodium falciparum 
2005-12-31 | E-MEXP-319 | biostudies-arrayexpress
TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
ProteomicsCSA-FLAG UV Treatment - TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A
SILAC comparison between CSA interactome before and after UV treatment.
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008863 | Pride
Csa Uv treatment Silac Flag 
GenomicsRenal Cyclosporin-A (CsA) toxicity
Renal Cyclosporin-A (CsA) toxicity
PRJNA437288 | ENA
TranscriptomicsAngII-regulated genes sensitive to CsA in Vascular Smooth muscle cells.
We have employed whole genome microarray expression profiling as a platform to identify AngII -regulated genes sensitive to CsA. VSMC were treated with AngII with or without CsA ( as an inhibitor of the CN/NFAT pathway). 4 independent VSMC cultures (4 replicates) from aortas of C57BL/6 mice were u...
ORGANISM(S): Mus musculus 
2011-08-10 | E-GEOD-31321 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human naive and HVC-replicon containing Huh7 cells were treated with CsA or NIM811 to investigate mode of action of these drugs and identified host factors essential for HCV replication in a subgenomic replicon model.
Cyclophilin binding drugs, NIM811 and cyclosporin A (CsA), inhibit the replication of HCV replicon. We investigated the mode of action of these drugs and identified host factors essential for HCV replication in a subgenomic replicon model. Experiment Overall Design: Cultured Huh7 cell were treated w...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-15935 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pulmonary valve endothelial cells treated in culture by VEGF and VEGF+CsA
Transcription profiling of human pulmonary valve endothelial cells treated in culture by VEGF and VEGF+CsA
ORGANISM(S): Homo sapiens 
2010-08-17 | E-TABM-765 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skin samples from atopic dermatitis patients before and after treatment with cyclosporine A
After 2 and 12 weeks of treatment, we observed significant reductions of 51% and 72%, respectively, in SCORAD scores. Clinical improvements were associated with significant gene expression changes in lesional but also nonlesional skin, particularly reductions in levels of TH2-, TH22-, and some TH17-...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-58558 | biostudies-arrayexpress
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