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MetabolomicsDefective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in liver
Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. Mitochondrial gene expression is essential for OXPHOS biogenesis since core subunits of the complexes are mitochondrial-encoded. CO...
2024-07-19 | MTBLS9823 | MetaboLights
MetabolomicsMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth

The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here w...

2020-06-29 | MTBLS1764 | MetaboLights
TranscriptomicsTranscription profiling of human glioblastomas identifies the major molecular basis for the prognostic benefit of younger age
Background: Glioblastomas are the most common primary brain tumour in adults. While the prognosis for patients is poor, gene expression profiling has detected signatures that can sub-classify GBMs relative to histopathology and clinical variables. One category of GBM defined by a gene expression s...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-13041 | biostudies-arrayexpress
UnknownRole of COX-2-derived PGE2 on vascular stiffness and function in hypertension.
Not available
S-EPMC4831311 | biostudies-literature
ProteomicsInteracting partners of Rac1 (P29S/Q61L) compared to constitutively active Rac1 (Q61L)
Interactors of double mutant Rac1 (P29S/Q61L) compared to constitutively active Rac1 (Q61L).
ORGANISM(S): Chlorocebus sabaeus 
2019-11-12 | PXD013941 | Pride
Cos7 cells Rac1 Gfp trap pulldown 
TranscriptomicsMapping origins of replication in Arabidopsis thaliana: H4K5ac ChIP vs. unmodified H3 ChIP
Genomic integrity requires faithful chromosome duplication. Origins of replication are the genomic sites where DNA replication initiates in every cell cycle. There are multiple origins scattered throughout the eukaryotic genome whose genome-wide identification has been a hard challenge, especially i...
ORGANISM(S): Arabidopsis thaliana 
2011-11-06 | E-GEOD-21827 | biostudies-arrayexpress
UnknownReplenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration.
Not available
S-EPMC10557650 | biostudies-literature
UnknownSurvival analysis and prognosis of patients with breast cancer with pleural metastasis.
Not available
S-EPMC10183576 | biostudies-literature
TranscriptomicsA family of secreted pathogenesis-related proteins in Candida albicans
Analyzing culture supernatants of yeast and hyphal cells of Candida albicans by mass spectrometry, we found two close homologues of pathogenesis-related (PR-) 1 proteins, Rbe1p and Rbt4p, in the secretome of this human pathogen. By sequence homology, we assigned three yet not characterized open read...
ORGANISM(S): Candida albicans 
2013-03-25 | E-GEOD-28212 | biostudies-arrayexpress
TranscriptomicsMapping origins of replication in Arabidopsis thaliana
Genomic integrity requires faithful chromosome duplication. Origins of replication are the genomic sites where DNA replication initiates in every cell cycle. There are multiple origins scattered throughout the eukaryotic genome whose genome-wide identification has been a hard challenge, especially i...
ORGANISM(S): Arabidopsis thaliana 
2011-02-06 | E-GEOD-21828 | biostudies-arrayexpress
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