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MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine kidney and plasma UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS680 | MetaboLights
MetabolomicsCyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs (Murine and human plasma quantitative L-arginine and methylarginines UPLC-MS/MS assay)

BACKGROUND: Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)-2, especially prostacyclin. An alternative mechanis...

2019-08-22 | MTBLS685 | MetaboLights
TranscriptomicsExpression profiling defines a recurrence signature in lung squamous cell carcinoma
Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is about 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disea...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5123 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR knockout screen to identify genes involved in macrophage differentiation
To identify genes involved in macrophage differentiation, a genome-wide CRISPR knockout library in macrophage progenitors was differentiated into macrophages. Samples were collected from the progenitor library at day 0, from a library maintained as progenitors for seven days, and from macrophages af...
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15740 | biostudies-arrayexpress
GenomicsGenome-wide CRISPR knockout screen in Mycobacterium tuberculosis infected macrophages to identify regulators of TNF and iNOS expression
To elucidate the early regulators of inflammation during Mycobacterium tuberculosis infection, we performed a genome-wide CRISPR knockout screen in macrophages to identify genes that influence the induction of TNF and iNOS upon infection. A genome-wide knockout library in murine macrophages was infe...
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15739 | biostudies-arrayexpress
TranscriptomicsRNA-seq profiling of Listeria monocytogenes infected macrophages lacking Irf2, Irf9, or Irf2 and Irf9, as well as scramble controls
RNA-seq profiling of macrophages lacking Irf2, Irf9, or Irf2 and Irf9, as well as scramble controls was performed. Macrophages were infected with Listeria monocytogenes or uninfected under mock conditions and total RNA was harvested 2 hours post infection.
ORGANISM(S): Mus musculus 
2026-04-29 | E-MTAB-15742 | biostudies-arrayexpress
TranscriptomicsClinical and Molecular Characteristics of Congenital Glioblastoma Multiforme
Congenital glioblastoma multiforme (cGBM) historically has been considered an aggressive tumor of infancy requiring extensive chemotherapy to achieve cure. We report on 4 patients at our institution with cGBMs who were treated with surgery and chemotherapy (carboplatin and etoposide every 21 days fo...
ORGANISM(S): Homo sapiens 
2012-05-20 | E-GEOD-32374 | biostudies-arrayexpress
UnknownRecovery From COVID-19 in Multiple Sclerosis: A Prospective and Longitudinal Cohort Study of the United Kingdom Multiple Sclerosis Register.
Not available
S-EPMC8631790 | biostudies-literature
ProteomicsThrombo-Inflammation in Preeclampsia and Pregnancy Induced Hypertension: Proteomics And Metabolomics Profiling of Platelets and Plasma Mediators
Background: Platelets may be pivotal mediators of the thrombo-haemorrhagic complications of preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular dysfunction. While gestational hypertension (GH) falls within the spectrum of hypertensive complications of pregnancy and i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD031278 | Pride
Metabolomics String bg Preeclampsia Pregnancy Gestational hypertension Proteomics Pathway analysis Lrrc27/42 
UnknownDisease-modifying therapy initiation patterns in multiple sclerosis in three large MS populations.
Not available
S-EPMC10943712 | biostudies-literature
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