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ProteomicsCDK4/6 inhibitors induce repication stress to cause long-term cell cycle withdrawal
CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are licenced to treat breast cancer and are also undergoing clinical trials against a range of other tumour types. To facilitate these efforts, it is important to understand why a temporary cell cycle arrest in G1 causes long-lasting effects ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD023435 | Pride
Cdk4/6 cancer replication stress cell cycle senescence 
UnknownCoordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration
Not available
S-JCBD-201002067 | bioimages
ProteomicsCyclin A triggers Mitosis either via Greatwall or Cyclin B
Two mitotic Cyclins, A and B, exist in higher eukaryotes, but their specialised functions in mitosis are poorly understood. Using degron tags we analyse how acute depletion of these proteins affects mitosis. Loss of Cyclin A in G2-phase prevents the initial activation of Cdk1. Cells lacking Cyclin B...
ORGANISM(S): Homo sapiens (Human) 
2020-05-21 | PXD012100 | Pride
Human Phosphoproteomics Cyclin Cell cycle Mitosis 
TranscriptomicsTranscription profiling of human bronchial epithelial cells treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.
Human bronchial epithelial cells were treated with vehicle (control), VOSO4 (V, 50 uM) or ZnSO4 (Zn, 50 uM) for 4 hours.
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2111 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of DNA from two recently divergent mouse strains, 12925 and C57BL/6J
We have performed CGH analysis using 129S5 DNA competitively hybridised with C57BL/6J DNA to RPCI-23 (C57BL/6J) BAC clones spotted at 1Mb resolution (array protocol 7769)
ORGANISM(S): Mus musculus 
2005-04-01 | E-MEXP-298 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human brain, spleen, skeletal muscle and whole blood identifies tissue-specific methylation at developmental gene loci
To compare the CpG Island methylome of human tissues.
ORGANISM(S): Homo sapiens 
2008-01-09 | E-MEXP-1391 | biostudies-arrayexpress
ProteomicsProteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS
The temporal regulation of protein abundance and post-translational modifications is a key feature of cell division. Recently, we analysed gene expression and protein abundance changes during interphase under minimally perturbed conditions (Ly et al. 2014; Ly et al. 2015). Here we show that by using...
ORGANISM(S): Homo sapiens (Human) 
2017-10-18 | PXD007787 | Pride
Human Facs Cell cycle 
UnknownA body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort.
Not available
S-EPMC10278318 | biostudies-literature
UnknownSame data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology.
Not available
S-EPMC11804095 | biostudies-literature
UnknownEffect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC8491132 | biostudies-literature
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