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ProteomicsFrom Sea to Therapy: Development and analytical control of recombinant human CDKL5 production in the marine bacterium Pseudoalteromonas haloplanktis TAC125
Marine bacteria are increasingly explored as alternative microbial platforms for the production of high-value biopharmaceuticals, owing to their distinctive physiological and biochemical features. In this study, we focus on the Antarctic marine bacterium Pseudoalteromonas haloplanktis TAC125 (PhTAC1...
ORGANISM(S): Pseudoalteromonas haloplanktis 
2026-05-29 | PXD073800 | Pride
Antarctic marine bacteria  cell-factory  difficult to express proteins  elisa  hcdkl5  protein phosphorylation  pseudoalteromonas haloplanktis tac125  quality by design. 
ProteomicsEnzyme replacement therapy for Fabry disease: possible strate-gies to improve its efficacy
Enzyme Replacement Therapy is the only therapeutic option for Fabry patients with completely absent AGAL activity. However, it has many limitations, in terms of costs, high rh-protein re-quired, and side effects; thus, its optimization would be beneficial for patients. In this paper, we describe pre...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039168 | Pride
Fabry disease  drug repositioning  interactome  gla  fabrazyme  replagal. 
MetabolomicsDysregulation of lipid metabolism and pathological inflammation in patients with COVID-19
In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 patients show mild, moderate or severe symptoms with the latter ones requiring access to specialized intensive care. SARS-CoV-2 infec...
2023-02-01 | MTBLS6844 | MetaboLights
ProteomicsThe identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism
6-Nitrodopamine Q7 Q8 (6-ND Q9 ) has potent positive chronotropic and inotropic effects. At a very low dose, i.e., 10 fM, it causes potentiation of the positive chronotropic effects induced by catecholamines in the rat atria, indicating a distinct mechanism of action. Cyclase-associated proteins (CA...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD066711 | Pride
Adrenaline Stromal interaction molecule 1 Cyclase- q10 associated proteins Dopamine Nitro-catecholamine 
ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059593 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
ProteomicsIntegrating Proteomics and Bioinformatics Methods for the Identification of Breast Cancer Biomarkers Interacting with Telomeric G-Quadruplex
The identification of reliable biomarkers is imperative for enhancing early detection, prognosis, and treatment of breast cancer. This study investigates a human telomeric dimeric G-quadruplex (G4) model, Tel46, which has been functionalized on Controlled Pore Glass (CPG) support, as a novel tool fo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD059597 | Pride
Bioinformatics Telomeric g-quadruplex Proteomics Dna-protein interactions. Breast cancer biomarkers 
UnknownNew label-free methods for protein relative quantification applied to the investigation of an animal model of Huntington Disease.
Not available
S-EPMC7473538 | biostudies-literature
UnknownThermophilic biocatalysts for one-step conversion of citrus waste into lactic acid.
Not available
S-EPMC10799777 | biostudies-literature
UnknownLysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A-Treated Stem Cells.
Not available
S-EPMC7921975 | biostudies-literature
ProteomicsNew label free methods for protein relative quantification applied to the investigation of animal model of Huntington Disease.
Spectral Counts approaches (SpCs) are largely employed for the comparison of protein expression profiles in label free differential proteomics applications. Similarly, to other comparative methods, also SpCs based approaches require a normalization procedure before Fold Changes (FC) calculation. Her...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-18 | PXD017471 | Pride
Label free methods  spectral counts normalization  complexity-based correction factor  huntington disease mice models 
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