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ProteomicsThe identification of adenylyl cyclase modulators as potential receptors for 6-nitrodopamine in human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes and their relevance in heart inotropism
6-Nitrodopamine Q7 Q8 (6-ND Q9 ) has potent positive chronotropic and inotropic effects. At a very low dose, i.e., 10 fM, it causes potentiation of the positive chronotropic effects induced by catecholamines in the rat atria, indicating a distinct mechanism of action. Cyclase-associated proteins (CA...
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD066711 | Pride
Adrenaline Stromal interaction molecule 1 Cyclase- q10 associated proteins Dopamine Nitro-catecholamine 
TranscriptomicsTranscription profiling of rat adrenal glands from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto animals
We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA.
ORGANISM(S): Rattus norvegicus 
2007-11-01 | E-GEOD-1675 | biostudies-arrayexpress
TranscriptomicsNrf2-related oxidative stress response and impaired dopamine biosynthesis in a PC12 cell model of Huntington’s disease
Huntington’s disease (HD) is a devastating disease for which currently no therapy is available. It is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD gene, resulting in an expansion of polyglutamines at the N-terminal end of the encode...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-10581 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains
We performed Affymetrix MG-U74Av2 GeneChip experiements on mRNA from the adrenal glands of the BPH hypertensive and BPL hypotensive mouse strains. All mice were aged-matched at 5 weeks. We obtained the mice from Jackson Laboratories, Bar Harbor, ME.
ORGANISM(S): Mus musculus 
2007-10-12 | E-GEOD-1674 | biostudies-arrayexpress
TranscriptomicsEffect of brain death on gene expression in liver from rhesus macaque
The majority of transplanted organs are recovered from deceased donors after brain death (BD). BD has been hypothesized to compromise organ quality in part from the activation of systemic inflammation. The objective of this study was to characterize the immune response induced by BD in a well con...
ORGANISM(S): Macaca mulatta 
2012-06-27 | E-GEOD-22624 | biostudies-arrayexpress
ProteomicsThe Alpha-1A Adrenergic Receptor Regulates Fatty Acid-Dependent Oxidative Phosphorylation in the Mouse Heart
Aims: The sympathetic nervous system regulates numerous critical aspects of mitochondrial function in the heart through activation of adrenergic receptors (ARs) on cardiomyocytes. Chronic β-AR activation causes maladaptive alterations in cardiomyocyte metabolism that contribute to the pathobiology o...
ORGANISM(S): Mus Musculus (mouse) 
2024-08-15 | PXD044591 | JPOST Repository
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