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ProteomicsMouse ciliopathy-associated CPLANE proteins
Combining proteomics, in vivo imaging and genetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified and characterized a new genetic module, which we term CPLANE (ciliogenesis and planar polarity effector), and an extensive associated protein network. CPLA...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-15 | PXD004741 | Pride
"planar cell polarity” Mouse Ciliopathy “human genetics" Cplane 
UnknownCPLANE Complex and Ciliopathies.
Not available
S-EPMC9221175 | biostudies-literature
UnknownStructure of the ciliogenesis-associated CPLANE complex.
Not available
S-EPMC9012472 | biostudies-literature
UnknownThe human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
Not available
S-EPMC12219219 | biostudies-literature
ProteomicsThe human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture
We report on three families in which CPLANE2/RSG1 variants are associated with Oral-Facial-Digital syndrome. Experiments in Xenopus reveal these missense variants to be “separation of function” alleles for Rsg1. Because one of the disease variants is within the GTP-binding pocket of the Rsg1 GTPas...
ORGANISM(S): Homo sapiens (Human) 
2025-07-01 | PXD055830 | Pride
Cilia Rsg1 Ciliopathy Gtpase Oral-facial-digital syndrome Cplane2 Cplane 
UnknownThe CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.
Not available
S-EPMC11006408 | biostudies-literature
UnknownThe CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation.
Not available
S-EPMC5964315 | biostudies-literature
GenomicsCPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.
CPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.
PRJNA1055040 | ENA
UnknownBiliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes.
Not available
S-EPMC10729795 | biostudies-literature
UnknownCPLANE protein INTU regulates growth and patterning of the mouse lungs through cilia-dependent Hh signaling.
Not available
S-EPMC11361757 | biostudies-literature
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