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ProteomicsTargeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
Benzoxaboroles (BoBs) feature a boron-heterocyclic core and are an important innovation in the development of drugs against a range of pathogens and other pathologies. A broad spectrum of pharmacology is associated with chemically diverse BoB derivatives and includes multiple modes-of-action (MoA) a...
ORGANISM(S): Trypanosoma brucei 
2026-02-13 | PXD074414 | Pride
Cpsf benzoxaboroles sumoylation 
GenomicsRITseq library analysis of benzoxabolores
Targeted protein degradation of the CPSF complex by benzoxaboroles through sumoylation
PRJEB122677 | ENA
TranscriptomicsTrypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057
Benzoxaboroles (BoBs) feature a boron-heterocyclic core and are an important recent innovation in the development of drugs against a range of pathogens and other pathologies. A broad spectrum of pharmacology is associated with chemically diverse BoB derivatives and includes multiple modes-of-action ...
ORGANISM(S): Trypanosoma brucei TREU927 
2024-03-08 | E-MTAB-13843 | biostudies-arrayexpress
ProteomicsTrypanosoma brucei whole cell proteome changes upon exposure to the aminomethyl-benzoxaborole AN3057
Benzoxaboroles (BoBs) feature a boron-heterocyclic core and are an important recent innovation in the development of drugs against a range of pathogens and other pathologies. A broad spectrum of pharmacology is associated with chemically diverse BoB derivatives and includes multiple modes-of-action ...
ORGANISM(S): Trypanosoma brucei 
2024-03-25 | PXD049328 | Pride
Benzoxaborole Sumo Trypanosoma Mode of action Cpsf complex Proteasome 
GenomicsAN3057 exposure
Trypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057
PRJEB72625 | ENA
GenomicsAN3057 exposure
Trypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057
PRJEB72626 | ENA
GenomicsTrypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057
Trypanosoma brucei transcriptome changes upon exposure to the aminomethyl-benzoxaborole AN3057
PRJEB72886 | ENA
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