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TranscriptomicsPHH Chlorpromazine
Drug induced liver injury (DILI) is still a major reason for drug attrition during clinical trials and market-withdrawal of already approved drugs. DILI is difficult to predict in animal models, hence more suitable screening methods are needed to predict adverse effects in human. Here, transcriptom...
ORGANISM(S): Homo sapiens 
2013-08-05 | E-MTAB-1747 | biostudies-arrayexpress
TranscriptomicsTREM2 regulates microglial cell activation in response to demyelination in vivo
Microglia are phagocytic cells that survey the brain and perform neuroprotective functions in response to tissue damage, but their activating receptors are largely unknown. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial immunoreceptor whose loss-of-function mutations in hum...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-70475 | biostudies-arrayexpress
GenomicsDeciphering the role of oligodendroglial Serpina3n in CPZ pathology using single-nucleus RNA sequencing
Deciphering the role of oligodendroglial Serpina3n in CPZ pathology using single-nucleus RNA sequencing
PRJNA1425504 | ENA
UnknownNovel perceptions of the involvement of CPZ in gastric cancer prognosis and immunomodulation.
Not available
S-EPMC12457134 | biostudies-literature
UnknownCPZ promotes the proliferation of gastric cancer by activating the Wnt pathway through binding with DVL2.
Not available
S-EPMC12605940 | biostudies-literature
TranscriptomicsDeciphering the role of oligodendroglial Serpina3n in CPZ pathology using single-nucleus RNA sequencing
Demyelination is a central pathological feature of multiple sclerosis and other neurodegenerative diseases, and the cuprizone (CPZ) diet is a widely used model for studying this process. In this study, we employed single-nucleus RNA sequencing (snRNA-seq) to investigate cellular and transcriptional ...
ORGANISM(S): Mus musculus 
2026-09-10 | GSE319903 | GEO
TranscriptomicsPHH treated with IBU, CPZ, CsA, AMI
Drug-induced hepatotoxicity is still one of the main reasons for drug attrition; therefore, there is an urgent need for more predictive models to identify the toxic potential of new drug candidates. Here, transcriptomic data from short- and long-term cultured primary human hepatocytes exposed to fou...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-MTAB-2473 | biostudies-arrayexpress
ProteomicsDistinct peptide profiles in CPZ-induced mouse
Here we performed peptidomic analysis of freshly isolated corpus callosum (CC) from the brains of CPZ-treated mice and normal diet controls of male C57BL/6 mice by LC-MS/MS. Identified a total of 217 peptides were expressed at different levels in MS mice model compared with controls.
ORGANISM(S): Mus Musculus 
2023-07-03 | PXD043468 |
Genomics
The effect of SDV on demyelination in CPZ model
PRJNA868498 | ENA
UnknownCommon variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.
Not available
S-EPMC5456408 | biostudies-literature
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