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TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (RNAi)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30990 | biostudies-arrayexpress
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
This SuperSeries is composed of the following subset Series: GSE30989: MOF-containing NSL complex specifically binds promoters of most, but stimulates only a specific subset of, housekeeping genes (ChIP-chip dataset) GSE30990: MOF-containing NSL complex specifically binds promoters of most, but stim...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30991 | biostudies-arrayexpress
TranscriptomicsCTD tyrosine phosphorylation impairs termination factor recruitment to transcribing RNA polymerase II
ChIP-chip was performed to identify the genomic binding locations for the termination factors Nrd1, and Rtt103, and for RNA polymerase (Pol) II phosphorylated at the tyrosine 1 and threonine 4 position of its C-terminal domain (CTD). In different phases of the transcription cycle, Pol II recruits di...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-29 | E-MTAB-1060 | biostudies-arrayexpress
UnknownSingle Particle Cryo-EM Reconstructions of NCP-CHD4 complexes
Not available
EMPIAR-10411 | biostudies-other
ProteomicsStructural basis of human transcription-DNA repair coupling
Transcription-coupled DNA repair (TCR) efficiently removes bulky DNA lesions from transcribed parts of the genome and constitutes a major defence against DNA damage by UV irradiation. TCR begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the Cockayne syndrome protein CsB, th...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-02-17 | PXD025328 | Pride
Protein-protein crosslinking Transcription-dna repair Ubiquitination analysis 
ProteomicsStructural basis of TFIIH activation for nucleotide excision repair
Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH). Here we report the cryo-EM structure of an NER intermediate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-02 | PXD013947 | Pride
Ner pathway Bs3 cross-linking 
UnknownStructure of replicating SARS-CoV-2 polymerase
Not available
EMPIAR-10409 | biostudies-other
UnknownSingle particle cryo-EM dataset of Sars-CoV2 Rna dependent RNA polymerase
Not available
EMPIAR-10741 | biostudies-other
UnknownTilt series of native M. pneumoniae cells treated with chloramphenicol
Not available
EMPIAR-10499 | biostudies-other
TranscriptomicsExpression profile of TAP tagged Tho2 strain
Tho2 protein was tagged with a TAP tag and the gene expression profile was compared to an untagged wildtype strain of the same background using DNA microarrays
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-24 | E-MTAB-1892 | biostudies-arrayexpress
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