Sort   by:  
 Page size 
ProteomicsCysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair
Tissue repair after myocardial infarction (MI) is guided by incompletely defined autocrine and paracrine-acting proteins. Deciphering these signals and their upstream triggers is essential when considering infarct healing as a therapeutic target. Searching for previously unknown growth factors invol...
ORGANISM(S): Homo sapiens (Human) 
2023-11-30 | PXD045013 | Pride
Phosphoproteomics Endothelial cells Cysteine-rich with egf-like domains 2 Creld2 Myocardial infarction Tissue repair 
GenomicsCreld2 function during unfolded protein response is essential for liver metabolism homeostasis
Creld2 function during unfolded protein response is essential for liver metabolism homeostasis
PRJNA599153 | ENA
GenomicsCRELD2 is a novel modulator of calcium mobilisation and calcineurin-NFAT signalling during osteoclast differentiation
CRELD2 is a novel modulator of calcium mobilisation and calcineurin-NFAT signalling during osteoclast differentiation
PRJNA835801 | ENA
ProteomicsSelective activation of PERK signaling mediates fibroblast education and tumor progression by a CRELD2-dependent mechanism
It is now well-accepted that cancers co-opt the microenvironment to support their growth. However, the molecular mechanisms underlying cancer-microenvironment interactions remain poorly defined. We have found that Rho-associated kinase (ROCK) activity in the epithelial component of mammary tumors se...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD018253 | Pride
Cancer progression Integrated stress response (isr) Unfolded protein response 25 (upr) Perk Cancer-associated fibroblasts (cafs) Breast cancer Endoplasmic reticulum (er)stress Rock 26 extracellular matrix Tumor microenvironment 
TranscriptomicsCreld2 function during unfolded protein response is essential for liver metabolism homeostasis
The unfolded protein response (UPR) is associated with the metabolic function of the liver, yet it is not well understood how endoplasmic reticulum (ER) disturbance might influence metabolic homeostasis. Here, we describe the physiological function of the Cysteine-rich with EGF-like domains 2 (Creld...
ORGANISM(S): Mus musculus 
2021-08-18 | GSE143185 | GEO
UnknownCreld2 function during unfolded protein response is essential for liver metabolism homeostasis.
Not available
S-EPMC12316087 | biostudies-literature
TranscriptomicsCRELD2 is a novel modulator of calcium mobilisation and calcineurin-NFAT signalling during osteoclast differentiation
Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the pathogenesis of skeletal dysplasias and has been shown to play a...
ORGANISM(S): Mus musculus 
2022-08-24 | GSE199189 | GEO
UnknownCRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation.
Not available
S-EPMC9381524 | biostudies-literature
GenomicsEndothelial cell-secreted bone targeting exosomes promote angiogenesis coupling with osteogenesis via the PERK-ATF4-CRELD2 pathway
Endothelial cell-secreted bone targeting exosomes promote angiogenesis coupling with osteogenesis via the PERK-ATF4-CRELD2 pathway
PRJNA1215745 | ENA
UnknownCysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair.
Not available
S-EPMC11358006 | biostudies-literature
Sort   by:  
 Page size