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ProteomicsA genetically-encoded crosslinker screen identifies SERBP1 as a PKC substrate influencing translation and cell division
The PKC-regulated genome protective pathway provides transformed cells a failsafe to successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it is unclear whether its requirement is sufficient or if other PKC cell cycle targets are involved. To address this, we deve...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD029091 | Pride
Human 
ProteomicsLack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
Hypoxia Inducible Factor (HIF) prolyl hydroxylase domain (PHD) enzymes catalyse the posttranslational hydroxylation of conserved prolyl residues in the alpha-subunit of the HIF transcription factor. These modifications, which promote the degradation of HIF-alpha subunits by the pVHL E3 ligase comple...
ORGANISM(S): Homo sapiens (Human) 
2019-08-30 | PXD013112 | Pride
Human Lc-msms In vitro Phd enzyme Prolyl hydroxylation 
UnknownPervasive chromosomal instability and karyotype order in tumour evolution.
Not available
S-EPMC7611706 | biostudies-literature
ProteomicsCoordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention
The N371 site on PKCe was mutated to TAG in an expression plasmid. This was co-transfected in a 1:1 ratio with a plasmid that encodes both an aaRS optimised to recognise AbK, and the tRNAPyl which recognises the UAG codon.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025959 | Pride
14-3-3 pkce Mass spectrometry Phosphorylation 
UnknownThe evolutionary history of 2,658 cancers.
Not available
S-EPMC7054212 | biostudies-literature
UnknownAnti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4.
Not available
S-EPMC10130092 | biostudies-literature
UnknownFine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Not available
S-EPMC4963094 | biostudies-literature
UnknownGermline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Not available
S-EPMC4872719 | biostudies-literature
UnknownInherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration.
Not available
S-EPMC5340123 | biostudies-literature
UnknownCis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer.
Not available
S-EPMC4580986 | biostudies-literature
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