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GenomicsGenome-wide analysis of the role of FOG-1 in GATA-1 chromatin occupancy
We report ChIP-Seq data for GATA-1 and the FOG-binding mutant of GATA-1 (GATA-1^V205G) in G1ME cells, a Gata1-null cell line with both erythroid and megakaryocytic differentiation potential. We introduced HA-tagged GATA-1 or V205G into G1ME cells via retroviral transduction. The cells were crossli...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-35644 | biostudies-arrayexpress
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
GenomicsGenome-wide transcription factor binding and chromatin methylation marks in the G1ME megakaryocytic progenitor model cell line
There are many examples of transcription factor families whose members control gene expression profiles of diverse cell types. However, the mechanism by which closely related factors occupy distinct regulatory elements and impart lineage specificity is largely undefined. Here we demonstrate on a gen...
ORGANISM(S): Mus musculus 
2012-03-05 | E-GEOD-31331 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of DYRK1A-deficient (CKO) pre-B and pre-T cells
Pre-B and pre-T lymphocytes must orchestrate a transition from a highly proliferative state to a quiescent one during development. Cyclin D3 is essential for these cells’ proliferation, but little is known about its post-translational regulation at this stage. Here, we show that the dual specificity...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-67052 | biostudies-arrayexpress
TranscriptomicsThe role of FOG-1 in GATA-1 transcriptional regulation of megakaryocyte differentiation
We explored the role of FOG-1 in GATA-1 transcriptional regulation of megakaryocyte differentiation through expression of wild-type GATA-1 and the FOG-binding mutant of GATA-1 (GATA-1^V205G) in G1ME cells. G1ME cells were derived from Gata1-null mouse ES cells and have both megakaryocyte and erythro...
ORGANISM(S): Mus musculus 
2012-03-05 | E-GEOD-35695 | biostudies-arrayexpress
UnknownPolylactic- Glycolic Acid Microparticles-Encapsulated Prostaglandin E1 as A Novel Strategy In Triple Negative Breast Cancer.
Not available
S-EPMC12680548 | biostudies-literature
UnknownA CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia Pathogenesis.
Not available
S-EPMC6235627 | biostudies-literature
TranscriptomicsETS2, ERG promote megakaryopoiesis, synergize with alterations in GATA1 to immortalize hematopoietic progenitor cells
Serial replated GFP + lineage negative cells from Gata1deltaneodeltaHS fetal liver hematopoietic progenitors for 4 generations in methocult M3234 under megakaryocyte promoting conditions, IL3, TPO, IL6, and IL11. Cells were subject to retro-viral infection with MIGR1GFP, MIGR1ETS2, MIGR1ERG, and MIG...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-14506 | biostudies-arrayexpress
UnknownHuman Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies.
Not available
S-EPMC9900323 | biostudies-literature
ProteomicsIdentification of RNA Pol II polymerase interactome in ALL cells
RNA polymerase II is a protein encoded by the POLR2A gene in humans. In coordination with a wide array of interacting partners, RNA polymerase II has been shown to participate in the regulation of the cell cycle, transcription, and splicing, all of which are important for ALL growth. Here, we invest...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048846 | Pride
Rna polymerase ii  acute lymphoblastic leukemia  proteomics  proteome 
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