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ProteomicsComparative analysis of the structural dynamics of diphtheria toxin and CRM197 carrier proteins used in the development of conjugate vaccines
Carrier proteins are chemically linked to poorly immunogenic antigens to generate conjugate vaccines, which have significantly improved immunization strategies in recent decades. CRM197, a genetically detoxified diphtheria toxin (DT) mutant carrying the G52E mutation, is a widely used carrier protei...
ORGANISM(S): Escherichia coli Corynebacterium diphtheriae 
2025-04-07 | PXD057388 | Pride
Comparative analysis Crm197 Structural characterization Hydrogen/deuterium exchange mass spectrometry (hdx-ms) Biopharmaceutical products 
UnknownEfficient recovery of recombinant CRM197 expressed as inclusion bodies in E.coli.
Not available
S-EPMC6051658 | biostudies-literature
UnknownStructural basis for lack of toxicity of the diphtheria toxin mutant CRM197.
Not available
S-EPMC3325714 | biostudies-literature
UnknownInvestigating the Deoxyribonuclease Activity of CRM197 with Site-Directed Mutagenesis.
Not available
S-EPMC6682014 | biostudies-literature
UnknownThe geometry of diphtheria toxoid CRM197 channel assessed by thiazolium salts and nonelectrolytes.
Not available
S-EPMC8390859 | biostudies-literature
UnknownThe inhibitory effect and targets of CRM197 on tumor growth in arsenic-transformed cells and lung cancer cells.
Not available
S-EPMC12623889 | biostudies-literature
UnknownStructure-guided design and evaluation of CRM197-scaffolded vaccine targeting GnRH for animal immunocastration.
Not available
S-EPMC11550287 | biostudies-literature
UnknownSafety and immunogenicity of meningococcal ACWY CRM197-conjugate vaccine in children, adolescents and adults in Russia.
Not available
S-EPMC4896799 | biostudies-literature
TranscriptomicsPneumococcal conjugate vaccination at birth induces robust recall responses at 9 months of age.
The objective of this study was to compare recall responses to vaccine antigens at 3 months and 9 months of age in infants who were vaccinated at birth or at 1 month. PBMC were obtained at 9 months of age from infants who were vaccinated at birth (n=25) or 1 month (n=25). The PBMC were cultured in t...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-25263 | biostudies-arrayexpress
UnknownProduction in Escherichia coli of recombinant COVID-19 spike protein fragments fused to CRM197.
Not available
S-EPMC8057744 | biostudies-literature
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