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ProteomicsThe majority of viral peptides displayed on class I MHC are immunogenic during infection
CD8+ T cells are essential effectors in anti-viral immunity, recognising short virus-derived peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the fraction of viral pMHCI on infected cells that are immunogenic has not been shown for any virus. To approach this fund...
ORGANISM(S): Mus musculus (Mouse) Vaccinia virus WR 
2019-01-23 | PXD010811 | Pride
Mouse Vaccinia virus Lc-ms/ms 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstra...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD009660 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
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