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MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (untargeted fecal metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4932 | MetaboLights
MetabolomicsSodium Butyrate mediates Histone Crotonylation and Alleviated Neonatal Rats Hypoxic-Ischemic Brain Injury Through Gut-Brain Axis (targeted SCFA brain metabolomics)

Neonatal hypoxic-ischemic encephalopathy (HIE) refers to nervous system damage caused by perinatal hypoxia, which is the major cause of long-term neuro-developmental disorders in surviving infants. However, the mechanisms still require further investigation. In this study, we found that the butan...

2022-10-12 | MTBLS4933 | MetaboLights
ProteomicsFirst comprehensive proteome analysis of lysine crotonylation in Streptococcus agalactiae, a pathogen causing meningoencephalitis in teleosts
In Homo sapiens, Streptococcus agalactiae is a common colonizer of the rectovaginal tract and a fundamental cause of neonatal and non-pregnant adults infectious diseases. It also causes infectious disease in fish which compromises food safety as well as possesses a zoonotic risk. Lysine crotonylatio...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2021-12-30 | PXD026445 | Pride
Streptococcus agalactiae  crotonylation  virulence factors  proteomics 
GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
ProteomicsA comprehensive proteome-wide lysine crotonylation profiling of papaya (Carica papaya L.)
Lysine crotonylation of histone proteins is a recently-identified post-translational modification with multiple cellular functions. However, lysine crotonylation of non-histone proteins in fruit cells has not yet been studied. Using high-resolution LC-MS/MS coupled with highly sensitive immune-affin...
ORGANISM(S): Carica papaya 
2017-12-18 | PXD008166 | Pride
Amino acid metabolism  cell wall  crotonylation  fruit ripening  papaya  ptm 
ProteomicsProteomes and Histone Crotonylation Analysis Reveals the Importance of Crotonylation Low Temperature in Chrysanthemum
Chrysanthemum is a garden plant with good economic benefit and high ornamental value. Chrysanthemum in the key period of flowering in autumn and winter, vulnerable to cold damage, affecting the normal growth of the chrysanthemum plant and even death. little is known regarding the study of histone cr...
ORGANISM(S): Dracocephalum grandiflorum 
2021-01-04 | PXD010297 | Pride
Proteome chrysanthemum  crotonylation 
ProteomicsHistone lysine acetylation, butyrylation, and crotonylation dynamics and functional interplay in rice under starvation and submergence
Histone lysine acylations are regulated by primary metabolism in animal cells. However, histone non-acetyl acylation is not yet studied in plants that have distinct primary metabolic pathways. In this work, we detected rice histone lysine butyrylation (Kbu) and crotonylation (Kcr) sites by mass spec...
ORGANISM(S): Oryza sativa (Rice) 
2018-09-06 | PXD009091 | Pride
Crotonylation Butyrylation Histone Rice 
ProteomicsGlobal Proteomic Analysis of Lysine crotonylation in The Plant Pathogen Botrytis cinerea
Lysine crotonylation (Kcr), a recently discovered post-translational modification, plays a key role in the regulation of diverse cellular processes. Botrytis cinerea is a destructive necrotrophic fungal pathogen distributed worldwide with broad ranging hosts. However, the functions of Kcr are unknow...
ORGANISM(S): Caenorhabditis elegans 
2020-09-07 | PXD019358 | Pride
Lc-ms/ms Botrytis cinerea Lysine crotonylation 
ProteomicsGlobal Lysine Crotonylation Alterations of Host Cell Proteins Caused by Brucella GNAT Containing Effector BspF
In Brucella spp., the type IV secretion system (T4SS) is essential for bacterial intracellular survival and inhibition of the host innate immune response. The Brucella T4SS secretes 15 different effectors to escape host immunity and promote intracellular replication. Among them, BspF has a GNAT-fami...
ORGANISM(S): Brucella sp. 
2021-09-09 | PXD021423 | Pride
Brucella  t4ss  effector  bspf  lysine crotonylation  crotonyltransferase 
ProteomicsThe Role of CDYL-Regulated Crotonylation of RPA1 in Homologous Recombination-Mediated DNA Repair
Lysine crotonylation (Kcr) is a recently-identified protein short-chain acylation. We have previously reported that chromodomain Y-like transcription corepressor CDYL acts as a crotonyl-CoA hydratase and negatively regulates histone Kcr. However, the global crotonylome of CDYL-regulated Kcr on non-h...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD013616 | Pride
Cdyl crotonylation  rpa1 dna repair 
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