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ProteomicsLC-MS/MS analysis of phosphorylation modifications of CRTC2 in IR-treated HCCLM3 cells
To systematically identify interaction proteins and phophorylation modifications of CRTC2 in response to DNA damage, we performed PTM assessments by using unbiased, label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) with CRTC2 pulldown lysates from irradiation (IR)-treated HCCLM3 c...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD068727 | Pride
Human Crtc2 Liver cancer Lc-ms/ms 
GenomicsDNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect
DNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect
PRJNA1314142 | ENA
GenomicsCRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance (CRTC2-RIPseq)
CRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance (CRTC2-RIPseq)
PRJNA1101517 | ENA
GenomicsCREB Coactivators CRTC2 and CRTC3 Modulate Bone Marrow Hematopoiesis
CREB Coactivators CRTC2 and CRTC3 Modulate Bone Marrow Hematopoiesis
PRJNA407926 | ENA
GenomicsDNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect [CUT&Tag]
DNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect [CUT&Tag]
PRJNA1310967 | ENA
GenomicsDNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect [RNA-Seq]
DNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect [RNA-Seq]
PRJNA1311445 | ENA
UnknownSam68 promotes hepatic gluconeogenesis via CRTC2.
Not available
S-EPMC8185084 | biostudies-literature
GenomicsQuantitative Analysis of Wild Type and Crtc2 adipocyte-specific KO Epididymal primary adipocyte Transcriptomes
Quantitative Analysis of Wild Type and Crtc2 adipocyte-specific KO Epididymal primary adipocyte Transcriptomes
PRJNA855467 | ENA
OtherCRTC2 Forms Co-condensates with YTHDF2 that Enhance Translational Efficiency of m6A-Modified mRNAs to Drive Hepatocarcinogenesis and Lenvatinib Resistance (CRTC2-RIPseq)
As the third most common cause of cancer-related mortality, hepatocellular carcinoma (HCC) is a global health concern. Despite its prevalence, treatment options are limited, underscoring the need to identify potential therapeutic targets and strategies. Here, we identified amplification of CRTC2, si...
ORGANISM(S): Homo sapiens 
2025-02-08 | GSE264239 | GEO
TranscriptomicsDNA-PK Mediated CRTC2 Phosphorylation Promotes CRTC2 Relocation from Transcription to Repair Complexes Enhancing NHEJ and Suppressing Abscopal Effect
DNA damage repair and transcription are antagonistic cellular processes that require precise spatiotemporal coordination to maintain genomic integrity. Transcriptional silencing at DSB sites is essential for efficient repair, mediated through localized histone modifications and direct inhibition of ...
ORGANISM(S): Mus musculus 
2026-04-20 | GSE307028 | GEO
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