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ProteomicsInterleukin-6 induced ‘acute’ response promotes Th1 anti-tumor immunity in cryo-thermal therapy: shotgun proteomics
Cryo-thermal therapy has been proven to be a promising novel systemic strategy for advanced breast cancer, resulting in higher incidence of tumor regression and enhanced remission of metastasis. The mechanism by which such strategy boosts the anti-tumor activity remains unclear. To gain a system-wid...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-12 | PXD003136 | Pride
Acute phase response Th1 anti-tumor immunity Cryo-thermal therapy Interleukin-6 Parallel reaction monitoring 
GenomicsEffects of Cryo-thermal therapy on gene expression in neutrophils and monocytes
Effects of Cryo-thermal therapy on gene expression in neutrophils and monocytes
PRJNA1080288 | ENA
GenomicsCryo-thermal therapy reprograms myeloid cells into CCL5+ mature phenotype to increase T cell infiltration and potentiates anti-PD-1 therapy
Cryo-thermal therapy reprograms myeloid cells into CCL5+ mature phenotype to increase T cell infiltration and potentiates anti-PD-1 therapy
PRJNA1392186 | ENA
Genomics
Combining ATRA Treatment Targeting MDSCs with Cryo-thermal Therapy in 4T1 breast cancer
PRJNA877562 | ENA
TranscriptomicsEffects of Cryo-thermal therapy on gene expression in neutrophils and monocytes
The characteristics of the tumor immunosuppressive microenvironment represent a major challenge limiting the efficacy of immunotherapy. Our previous results suggested that cryo-thermal therapy (CTT), a tumor ablation system developed in our laboratory, could promote macrophage M1-type polarization a...
ORGANISM(S): Mus musculus 
2024-03-02 | GSE259010 | GEO
UnknownSupplementation with Serum-Derived Extracellular Vesicles Reinforces Antitumor Immunity Induced by Cryo-Thermal Therapy.
Not available
S-EPMC8539038 | biostudies-literature
TranscriptomicsCryo-thermal therapy reprograms myeloid cells into CCL5+ mature phenotype to increase T cell infiltration and potentiates anti-PD-1 therapy
Although immune checkpoint blockade (ICB) represented by anti-PD-1 therapy has demonstrated significant clinical benefits, its efficacy remains limited by the immunosuppressive tumour microenvironment (TME). Cryo-thermal therapy (CTT) not only completely ablates local solid tumours by pre-freezing b...
ORGANISM(S): Mus musculus 
2026-03-01 | GSE314594 | GEO
UnknownCryo-thermal therapy elicits potent anti-tumor immunity by inducing extracellular Hsp70-dependent MDSC differentiation.
Not available
S-EPMC4891716 | biostudies-literature
UnknownDownregulated TNF-α Levels after Cryo-Thermal Therapy Drive Tregs Fragility to Promote Long-Term Antitumor Immunity.
Not available
S-EPMC8468796 | biostudies-literature
UnknownTh1-Dominant CD4+ T Cells Orchestrate Endogenous Systematic Antitumor Immune Memory After Cryo-Thermal Therapy.
Not available
S-EPMC9304863 | biostudies-literature
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