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Quantitative proteomics of cryptococcal meningitis brain tissues and control brain tissues was carried out to study the host factors that are activated and differentially regulated in response to infection. Proteins isolated from infected brain tissues were subjected to trypsin digestion and then la...
ORGANISM(S): Homo sapiens (Human) 
2015-07-22 | PXD000458 | Pride
Single-end reads of serial isolates from cryptococcal meningitis cases
Expression profiles of circRNAs in peripherial blood mononuclear cells from cryptococcal meningitis and healthy individuals.
CircRNAs are a recently well-known regulator that mediates a variety of biological processes. Cryptococcus neoformans is an environmental fungal pathogen that can cause fatal cryptococcal meningitis in immunocompromised individuals. However, the involvement of circRNA in cryptococcal infection remai...
ORGANISM(S): Homo sapiens 
2020-12-07 | GSE159601 | GEO
Ubiquitination is a reversible protein modification involved in various cellular processes in eukaryotic cells. Deubiquitinating enzymes, the proteins responsible for the removal of ubiquitin, act as essential regulators to maintain ubiquitin homeostasis and to exquisitely regulate protein degrada...
ORGANISM(S): Cryptococcus neoformans 
Objectives: Central nervous system (CNS) infections are common causes of morbidity and mortality worldwide. We aimed to discover protein biomarkers that could rapidly and accurately identify the likely cause of the infections, essential for clinical management and improving outcome. Methods: We app...
ORGANISM(S): Homo sapiens (Human) 
2020-08-20 | PXD020510 | Pride
Dynamic single-cell mapping of cerebrospinal fluid unveils immune suppressive states during cryptococcal meningitis
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