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MetabolomicsMoxibustion Inhibits Inflammation in Monosodium Urate Crystal-induced Gouty Arthritis Model Rats through Metabolomic Regulation

Background: Moxibustion is a form of therapy that to warm the acupoints located skin by using dried mugwort leaves. It is widely used to treat gouty arthritis (GA). However, the mechanism of moxibustion on improving GA has not been fully revealed. In this study, we explore the mechanism of moxibu...

2025-03-03 | MTBLS12225 | MetaboLights
ProteomicsUnveiling potential natural promoters of calcium oxalate kidney stones in the urine via anion exchange chromatography, crystal assays, and proteomics
Knowledge of natural stone promoters in the urine was previously limited, but is essential to develop new targets for better management of calcium oxalate (CaOx) kidney stones. This work, therefore, unveils such information in the urine of CaOx stone formers (patients with stones). Urinary proteins ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD075344 | Pride
Crystal  mass spectrometry  nephrolithiasis  proteome  stone modulators  urinary proteins 
GenomicsCrystal Geyser Travertine
Metagenomes Crystal Geyser travertine
PRJNA961082 | ENA
ProteomicsNeutrophil secretory proteins inhibit calcium oxalate crystallization and crystal growth, but promote crystal aggregation
Neutrophil secretory proteins are frequently found in calcium oxalate (CaOx) kidney stone matrix, suggesting their involvement in stone pathogenesis, but with unclear mechanisms. We therefore investigated the effects of secretome (a set of secretory proteins) from CaOx monohydrate (COM)-exposed vs. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD070785 | Pride
Immune  kidney stone  modulators  proteomics  secretome  stone modulation 
ProteomicsGenetic Control Over Biogenic Crystal Morphogenesis in Zebrafish
Organisms had to evolve mechanisms that regulate the properties of biogenic crystals to support a wide range of functions, from vision and camouflage to communication and thermal regulation. Yet, the mechanism underlying the formation of diverse intracellular crystals remains enigmatic. Here, we hav...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-07-31 | PXD052468 | Pride
Guanine Iridophore Substrate selectivity Controlled biosynthesis Paralogous enzymes Crystal morphogenesis 
TranscriptomicsStudy of transcriptional effects of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line.
Aim of the study was to characterize at a molecular level (changes in transcriptomes) the effect of monosodium urate crystal (MSU) on HaCaT keratinocyte cell line. This was adressed by using a culture model. The HaCaT cell line (human keratinocytes) was stimulated by MSU (1mg/mL) vs control for 12 h...
ORGANISM(S): Homo sapiens 
2015-10-29 | E-GEOD-65931 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of Drosophilalarval crystal cells
Crystal cells are one of the 3 Drosophila blood cell lineages and represent less than 5% of the total hemocytes in wild type larvae. There development is notably controlled by mlf (myeloid leukemia factor), which regulate their number by stabilising the lineage-specific transcription factor Lozenge....
ORGANISM(S): Drosophila melanogaster 
2017-07-20 | GSE93823 | GEO
GenomicsPotential Targets of Cholesterol Crystal Embolism
Potential Targets of Cholesterol Crystal Embolism
PRJNA1269532 | ENA
UnknownHydrogen bonding regulation-oriented design of pyridine sulfonate as a promising UV birefringent crystal characterized by enhanced structural anisotropy.
Not available
S-EPMC11840952 | biostudies-literature
GenomicsZea mays subsp. mays strain:White Crystal
Zea mays subsp. mays strain:White Crystal Transcriptome or Gene expression
PRJNA253977 | ENA
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