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TranscriptomicsRNA-Seq whole transcriptome analysis of normal human epidermal keratinocytes and cutaneous squamous cell carcinoma cell lines.
The incidence of keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is increasing worldwide making it the second most common metastatic skin cancer. In this project we used SOLiD next generation sequencing to characterize gene expression profiles in normal human epidermal ker...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66412 | biostudies-arrayexpress
TranscriptomicsAnalysis of the gene expression profile in normal human epidermal keratinocytes and cutaneous squamous cell carcinoma cell lines
The incidence of keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is increasing worldwide making it the second most common metastatic skin cancer. We used microarrays to characterize gene expression profile in normal human epidermal keratinocytes (NHEK) and cSCC cell lines....
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66359 | biostudies-arrayexpress
TranscriptomicsAnalysis of the gene expression profile in cutaneous squamous cell carcinoma cells after EphB2 knockdown
The role of Eph/ephrin signaling in numerous biological processes has been established. However, Eph/ephrin signaling has been shown to have complex role in tumor progression. The role of EphB2 receptor in the progression of cutaneous squamous cell carcinoma (cSCC) has not been studied before. EphB2...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66361 | biostudies-arrayexpress
ProteomicsProteomics study of skin tissues from RDEB cSCC, low-risk cSCC and metastasizing cSCC
Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in recessive dystrophic epidermolysis bullosa (RDEB) patients but remains poorly studied on a proteomic level. We aim to characterize the RDEB-SCC proteome by comparing it to the proteomes of UV-light induced cSCC of non-aggressi...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006914 | Pride
Recessive dystrophic epidermolysis bullosa  cutaneus squamous cell carcinoma  formalin-fixed paraffin-embedded tissue label-free quantitation  liquid chromatography – tandem mass spectrometry 
TranscriptomicsKey differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling
Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to inve...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-45216 | biostudies-arrayexpress
GenomicsRNA sequencing of 15 patient derived cSCC cell lines
RNA sequencing of 15 patient derived cSCC cell lines
PRJNA1108706 | ENA
TranscriptomicsEphB2 promotes progression of cutaneous squamous cell carcinoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66368 | biostudies-arrayexpress
GenomicsAnalysis of sncRNA expression in 22 primary cSCC
Analysis of sncRNA expression in 22 primary cSCC
PRJNA856135 | ENA
TranscriptomicsEpidermolysis bullosa associated cutaneous SCC fibroblast expression profiling
Patients with the genetic skin blistering disease recessive dystrophic epidermolysis bullosa (RDEB) develop aggressive cutaneous squamous cell carcinoma (cSCC). Metastasis leading to mortality is greater in RDEB than in other patient groups with cSCC. Here we investigate the dermal component in RDEB...
ORGANISM(S): Homo sapiens 
2012-05-15 | E-GEOD-37738 | biostudies-arrayexpress
TranscriptomicsEpigenome analysis of cutaneous squamous cell carcinoma samples
Genome wide DNA methylation profiling in cutaneous squamous cell carcinoma. The Infinium MethylationEPIC BeadChips 850K has been used to interrogate DNA methylation changes. The cohort included 23 patients in total, with precursors of squamous cell carcinoma (actinic keratosis group) and with cSCC a...
ORGANISM(S): Homo sapiens 
2019-12-12 | E-MTAB-8542 | biostudies-arrayexpress
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